| Title | 9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk |
| Authors | Xiao, Qin Gao, Shan Luo, Hui Fan, Wenguo Guo, Shicheng Yao, Hong Leng, Shuilong Xu, Zhenhua Tao, Tao Liu, Xingyan Zhang, Jingfang Zhang, Ming Li, Dongpei Xiao, Qin |
| Affiliation | Guangdong Med Coll, Dept Biochem, Key Lab Mol Diag, Dongguan, Peoples R China. Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Dept Transfus, Shenzhen, Peoples R China. Tianjin Univ, Sch Comp Sci & Technol, Tianjin 300072, Peoples R China. Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510275, Guangdong, Peoples R China. Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China. Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China. Chinese Univ Hong Kong, Li Ka Shing Inst Med Sci, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China. Guangzhou Med Univ, Dept Human Anat, Guangzhou, Guangdong, Peoples R China. Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Canc Cell Biol Program, Philadelphia, PA 19104 USA. Shandong Prov Zibo Cent Hosp, Dept Canc, Ctr Clin Med Res, Zibo, Peoples R China. Georgia Regents Univ, Inst Mol Med & Genet, Augusta, GA 30901 USA. |
| Keywords | Lung squamous cell carcinoma MAPKAP1 SNPs Population attributable risk 9q33 3 HEPATOCELLULAR-CARCINOMA COMPLEX INTEGRITY CANCER GRP78 POLYMORPHISM PHOSPHORYLATION RS430397 HALLMARK RICTOR |
| Issue Date | 2014 |
| Publisher | journal of thoracic oncology |
| Citation | JOURNAL OF THORACIC ONCOLOGY.2014,9,(7),1041-1047. |
| Abstract | Background: Human chromosome 9q33.3 is one of the most important loci for pathophysiological stresses with complex genetic traits. We hypothesized that the common single-nucleotide polymorphisms on this region may affect non-small-cell lung cancer risk. Methods: We genotyped 43 single-nucleotide polymorphisms that span 13 genes on 9q33.3 in two independent cohorts: the discovery study including 485 cases and 532 controls (North China) and the replicative study including 1063 cases and 1247 controls (South China). Both of the discovery cohort and the replicative cohort were included in the combined study. Results: In the discovery study, we identified a potential protective locus rs10118570 in mitogen-activated protein kinase associated protein 1 with a lower population attributable risk under logistical regression adjusted by age, gender, smoking, and drinking status (adjusted odds ratio [OR] 0.26, 95% confidence interval [CI] 0.10-0.71, p = 1.138 x 10(-3) for genotype GG in lung squamous cell carcinoma). This protective quality increased in a dose-dependent manner as genotype GG decreased (p(trend) = 9.675 x 10(-4)). Replicative and combined studies showed consistent association for this genotype (replicative: adjusted OR 0.36, 95% CI 0.20-0.66, p = 6.109 x 10(-4), p(trend) = 7.386 x 10(-4); combined: adjusted OR 0.33, 95% CI 0.18-0.55, p = 1.259 x 10(-6), p(trend) = 7.725 x 10(-6)). Conclusion: We concluded that mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma. |
| URI | http://hdl.handle.net/20.500.11897/342119 |
| ISSN | 1556-0864 |
| DOI | 10.1097/JTO.0000000000000195 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 深圳医院 |
