| Title | Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance |
| Authors | Xiao, Meng Fan, Xin Chen, Sharon C.A. Wang, He Sun, Zi-Yong Liao, Kang Chen, Shu-Lan Yan, Yan Kang, Mei Hu, Zhi-Dong Chu, Yun-Zhuo Hu, Tie-Shi Ni, Yu-Xing Zou, Gui-Ling Kong, Fanrong Xu, Ying-Chun |
| Affiliation | Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China. Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China. Univ Sydney, Westmead Hosp, ICPMR Pathol West, Ctr Infect Dis & Microbiol Lab Serv, Sydney, NSW 2006, Australia. Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Clin Lab, Wuhan 430074, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510275, Guangdong, Peoples R China. Harbin Med Univ, Affiliated Hosp 1, Dept Clin Lab, Harbin, Peoples R China. Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China. Sichuan Univ, West China Hosp, Lab Clin Microbiol, Chengdu 610064, Peoples R China. Tianjin Med Univ, Gen Hosp, Dept Clin Lab, Tianjin, Peoples R China. China Med Univ, Hosp 1, Dept Clin Lab, Shenyang 110001, Peoples R China. Peoples Hosp Liaoning Prov, Dept Clin Lab, Shenyang, Peoples R China. Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Clin Microbiol & Infect Control, Shanghai 200030, Peoples R China. Harbin Med Univ, Affiliated Hosp 4, Dept Clin Lab, Harbin, Peoples R China. |
| Keywords | China Hospital Invasive Fungal Surveillance Net (CHIF-NET) antifungal susceptibility non-albicans Candida species/species complexes C. parapsilosis species complex C. tropicalis C. glabrata species complex C. krusei EPIDEMIOLOGIC CUTOFF VALUES SENSITITRE YEASTONE METHOD BLOOD-STREAM INFECTIONS INTENSIVE-CARE UNITS FUNGAL-INFECTIONS MULTIDRUG-RESISTANCE CLINICAL BREAKPOINTS OPPORTUNISTIC YEAST TEMPORAL TRENDS DISK DIFFUSION |
| Issue Date | 2015 |
| Publisher | journal of antimicrobial chemotherapy |
| Citation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY.2015,70,(3),802-810. |
| Abstract | Objectives: To define the antifungal susceptibility patterns of the most common non-albicans Candida spp. in China. Methods: We evaluated the susceptibilities to nine antifungal drugs of Candida parapsilosis species complex, Candida tropicalis, Candida glabrata species complex and Candida krusei isolates from patients with invasive candidiasis at 11 hospitals over 3 years. Isolates were identified by MALDI-TOF MS supplemented by DNA sequencing. MICs were determined by Sensititre YeastOne (TM) using current clinical breakpoints/epidemiological cut-off values to assign susceptibility (or WT), and by CLSI M44-A2 disc diffusion for fluconazole and voriconazole. Results: Of 1072 isolates, 392 (36.6%) were C. parapsilosis species complex. C. tropicalis, C. glabrata species complex and C. krusei comprised 35.4%, 24.3% and 3.7% of the isolates, respectively. Over 99.3% of the isolates were of WT phenotype to amphotericin B and 5-flucytosine. Susceptibility/WT rates to azoles among C. parapsilosis species complex were >= 97.5%. However, 11.6% and 9.5% of C. tropicalis isolates were non-susceptible to fluconazole and voriconazole, respectively (7.1% were resistant to both). Approximately 14.3% of C. glabrata sensu stricto isolates (n = 258) were fluconazole resistant, and 11.6% of C. glabrata sensu stricto isolates were cross-resistant to fluconazole and voriconazole. All C. krusei isolates were susceptible/WT to voriconazole, posaconazole and itraconazole. Overall, 97.7%-100% of isolates were susceptible to caspofungin, micafungin and anidulafungin, but 2.3% of C. glabrata were non-susceptible to anidulafungin. There was no azole/echinocandin co-resistance. Disc diffusion and Sensititre YeastOne (TM) methods showed >95% categorical agreement for fluconazole and voriconazole. Conclusions: In summary, reduced azole susceptibility was seen among C. tropicalis. Resistance to echinocandins was uncommon. |
| URI | http://hdl.handle.net/20.500.11897/341770 |
| ISSN | 0305-7453 |
| DOI | 10.1093/jac/dku460 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
