| Title | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration |
| Authors | Ma, Liang Li, Ying Peng, Junya Wu, Danni Zhao, Xiaoxin Cui, Yitong Chen, Lilian Yan, Xiaojun Du, Yanan Yu, Li |
| Affiliation | Tsinghua Univ, Peking Univ, Sch Life Sci, Joint Ctr Life Sci,State Key Lab Biomembrane & Me, Beijing 100084, Peoples R China. Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China. Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China. |
| Keywords | migrasome migracytosis migration retraction fibers vesicle VESICLE FORMATION SECRETION EXOCYTOSIS INHIBITOR EXOSOMES FORM |
| Issue Date | 2015 |
| Publisher | 细胞研究英文版 |
| Citation | CELL RESEARCH.2015,25,(1),24-38. |
| Abstract | Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them "migrasomes". We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism "migracytosis". |
| URI | http://hdl.handle.net/20.500.11897/341654 |
| ISSN | 1001-0602 |
| DOI | 10.1038/cr.2014.135 |
| Indexed | SCI(E) PubMed 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 生命科学学院 |
