| Title | Diminished serum repetin levels in patients with schizophrenia and bipolar disorder |
| Authors | Wang, Shuai Ren, Huixun Xu, Jie Yu, Yanjun Han, Shuiping Qiao, Hui Cheng, Shaoli Xu, Chang An, Shucheng Ju, Bomiao Yu, Chengyuan Wang, Chanyuan Wang, Tao Yang, Zhenjun Taylor, Ethan Will Zhao, Lijun |
| Affiliation | Shaanxi Normal Univ, Coll Life Sci, Key Lab Minist Educ Med Plant Resource & Nat Phar, Xian 710062, Peoples R China. Xi An Jiao Tong Univ, Sch Med, Dept Pathogen Biol & Immunol, Xian 710061, Peoples R China. Xian Mental Hlth Ctr, Dept Clin Chem, Xian 710061, Peoples R China. Xi An Jiao Tong Univ, Sch Med, Dept Pathol, Xian 710061, Peoples R China. Shaanxi Normal Univ, Coll Life Sci, Xian 710062, Peoples R China. Xi An Jiao Tong Univ, Sch Med, Ctr Expt Morphol, Xian 710061, Peoples R China. Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. Univ N Carolina, Joint Sch Nanosci & Nanoengn, Dept Nanosci, Greensboro, NC 27401 USA. |
| Keywords | CHOROID-PLEXUS CALCIFICATION CALCIUM-BINDING-PROTEIN DORSOLATERAL PREFRONTAL CORTEX WIDE ASSOCIATION ANALYSIS LOCUS-CERULEUS PSYCHIATRIC-DISORDERS BARRIER FUNCTION GENE-EXPRESSION INCREASED S100B HIPPOCAMPUS |
| Issue Date | 2015 |
| Publisher | scientific reports |
| Citation | SCIENTIFIC REPORTS.2015,5. |
| Abstract | Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human brain, with relatively high levels in choroid plexus, hippocampus and prefrontal cortex. To investigate the expression of RPTN in neuropsychiatric disorders, we determined serum levels of RPTN in patients with schizophrenia (n = 88) or bipolar disorder (n = 34) and in chronic psychostimulant users (n = 91). We also studied its expression in a mouse model of chronic unpredictable mild stress (CUMS). The results showed that serum RPTN levels were significantly diminished in patients with schizophrenia and bipolar disorder or in psychostimulant users, compared with healthy subjects (n = 115) or age-matched controls (n = 92) (p < 0.0001). In CUMS mice, RPTN expression in hippocampus and prefrontal cortex was reduced with progression of the CUMS procedure; the serum RPTN level remained unchanged. Since CUMS is a model for depression and methamphetamine (METH) abuse induced psychosis recapitulates many of the psychotic symptoms of schizophrenia, the results from this study may imply that RPTN plays a potential role in emotional and cognitive processing; its decrease in serum may indicate its involvement in the pathogenesis of schizophrenia and bipolar disorder. |
| URI | http://hdl.handle.net/20.500.11897/341531 |
| ISSN | 2045-2322 |
| DOI | 10.1038/srep07977 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
