| Title | 5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection |
| Authors | Ma, Yina Li, Bingfeng Wang, Chenbo Shi, Zhenhao Sun, Yun Sheng, Feng Zhang, Yifan Zhang, Wenxia Rao, Yi Han, Shihui |
| Affiliation | Peking Univ, Dept Psychol, Beijing 100871, Peoples R China. Peking Univ, Sch Life Sci, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China. Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China. |
| Keywords | 5-HTTLPR anterior cingulate anterior insula FMRI negative self-schema SEROTONIN TRANSPORTER GENE MAJOR DEPRESSIVE DISORDER MEDIAL PREFRONTAL CORTEX EVENT-RELATED FMRI ANTIDEPRESSANT TREATMENT UNIPOLAR DEPRESSION HARM AVOIDANCE AFFECTIVE COMPONENTS INCREASED AMYGDALA PERSONALITY |
| Issue Date | 2014 |
| Publisher | cerebral cortex |
| Citation | CEREBRAL CORTEX.2014,24,(9),2421-2429. |
| Abstract | Cognitive distortion in depression is characterized by enhanced negative thoughts about both environment and oneself. Carriers of a risk allele for depression, that is, the short (s) allele of the serotonin transporter promoter polymorphism (5-HTTLPR), exhibit amygdala hyperresponsiveness to negative environmental stimuli relative to homozygous long variant (l/l). However, the neural correlates of negative self-schema in s allele carriers remain unknown. Using functional MRI, we scanned individuals with s/s or l/l genotype of the 5-HTTLPR during reflection on their own personality traits or a friend's personality traits. We found that relative to l/l carriers, s/s carriers showed stronger distressed feelings and greater activity in the dorsal anterior cingulate (dACC)/dorsal medial prefrontal cortex (dmPFC) and the right anterior insula (AI) during negative self-reflection. The 5-HTTLPR effect on the distressed feelings was mediated by the AI/inferior frontal (IF) activity during negative self-reflection. The dACC/dmPFC activity explained 20% of the variation in harm-avoidance tendency in s/s but not l/l carriers. The genotype effects on distress and brain activity were not observed during reflection on a friend's negative traits. Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression. |
| URI | http://hdl.handle.net/20.500.11897/323379 |
| ISSN | 1047-3211 |
| DOI | 10.1093/cercor/bht099 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 心理与认知科学学院 生命科学学院 |
