| Title | In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus |
| Authors | Sun, Chunguang Falagas, Matthew E. Wang, Rui Karageorgopoulos, Drosos E. Yu, Xuhong Liu, Youning Cai, Yun Liang, Beibei Song, Xiujie Liu, Zheyuan |
| Affiliation | Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Beijing 100853, Peoples R China. Peking Univ, Dept Pharm Adm & Clin Pharm, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China. Alfa Inst Biomed Sci, Athens, Greece. Henry Dunant Hosp, Dept Med, Athens, Greece. Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA. Chinese Peoples Liberat Army Gen Hosp, Dept Pulm Dis, Beijing 100853, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, 28 Fuxing Rd, Beijing 100853, Peoples R China. |
| Keywords | FICI fosfomycin minocycline MRSA synergism HOSPITALIZED-PATIENTS UNITED-STATES SUSCEPTIBILITY TIGECYCLINE INFECTIONS EPIDEMIOLOGY VANCOMYCIN PROGRAM SENTRY MRSA |
| Issue Date | 2011 |
| Publisher | journal of antibiotics |
| Citation | JOURNAL OF ANTIBIOTICS.2011,64,(8),559-562. |
| Abstract | This study aimed to evaluate the in vitro activity of minocycline combined with fosfomycin against isolates of methicillin-resistant Staphylococcus aureus (MRSA). A total of 87 clinical isolates of MRSA collected from three Chinese hospitals were included in the study. The checkerboard method with determination of the fractional IC index (FICI) was used to determine whether antibiotic combinations act synergistically against these isolates. The susceptibility results for minocycline and fosfomycin were interpreted according to the most relevant criteria. The results demonstrated the following interactions: 76 isolates (87.4%) showed synergistic interactions (FICI <= 0.5) and 11 isolates (12.6%) showed indifferent interactions (0.5<FICI<4). No antagonistic interactions (FICI >= 4) were observed. The combination of minocycline and fosfomycin can be synergistic against MRSA. Further studies are required to determine the potential clinical role of this combination regimen as a therapeutic alternative for certain types of MRSA infections. The Journal of Antibiotics (2011) 64, 559-562; doi:10.1038/ja.2011.52; published online 20 July 2011 |
| URI | http://hdl.handle.net/20.500.11897/323248 |
| ISSN | 0021-8820 |
| DOI | 10.1038/ja.2011.52 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 |
