| Title | New Efficient and Flexible Synthetic Route to Emivirine and Its Analogs |
| Authors | Li, Li Ma, Liying Wang, Xiaowei Liu, Junyi |
| Affiliation | Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China. Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent NCAIDS, Beijing 100050, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100191, Peoples R China. |
| Keywords | POTENT HEPT |
| Issue Date | 2013 |
| Publisher | journal of heterocyclic chemistry |
| Citation | JOURNAL OF HETEROCYCLIC CHEMISTRY.2013,50,(1),164-168. |
| Abstract | A revised synthetic route to Emivirine (MKC-442) via properly substituted beta-keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC-442 analogues and open the way for their systematic biological evaluation. |
| URI | http://hdl.handle.net/20.500.11897/323203 |
| ISSN | 0022-152X |
| DOI | 10.1002/jhet.987 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
