| Title | Co-methylated Genes in Different Adipose Depots of Pig are Associated with Metabolic, Inflammatory and Immune Processes |
| Authors | Li, Mingzhou Wu, Honglong Wang, Tao Xia, Yudong Jin, Long Jiang, Anan Zhu, Li Chen, Lei Li, Ruiqiang Li, Xuewei |
| Affiliation | Peking Univ, Peking Tsinghua Ctr Life Sci, Biodynam Opt Imaging Ctr, Beijing 100871, Peoples R China. Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China. Sichuan Agr Univ, Coll Anim Sci & Technol, Inst Anim Genet & Breeding, Yaan, Sichuan, Peoples R China. BGI Shenzhen, Shenzhen, Guangdong, Peoples R China. Chongqing Acad Anim Sci, Chongqing, Peoples R China. |
| Keywords | pig subcutaneous adipose tissue visceral adipose tissue DNA methylation MeDIP-seq INSULIN-RESISTANCE PERICARDIAL FAT TISSUE OBESITY MODEL ACID |
| Issue Date | 2012 |
| Publisher | international journal of biological sciences |
| Citation | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES.2012,8,(6),831-837. |
| Abstract | It is well established that the metabolic risk factors of obesity and its comorbidities are more attributed to adipose tissue distribution rather than total adipose mass. Since emerging evidence suggests that epigenetic regulation plays an important role in the aetiology of obesity, we conducted a genome-wide methylation analysis on eight different adipose depots of three pig breeds living within comparable environments but displaying distinct fat level using methylated DNA immunoprecipitation sequencing. We aimed to investigate the systematic association between anatomical location-specific DNA methylation status of different adipose depots and obesity-related phenotypes. We show here that compared to subcutaneous adipose tissues which primarily modulate metabolic indicators, visceral adipose tissues and intermuscular adipose tissue, which are the metabolic risk factors of obesity, are primarily associated with impaired inflammatory and immune responses. This study presents epigenetic evidence for functionally relevant methylation differences between different adipose depots. |
| URI | http://hdl.handle.net/20.500.11897/320218 |
| ISSN | 1449-2288 |
| DOI | 10.7150/ijbs.4493 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 |
