| Title | Expression of glycoprotein non-metastatic melanoma protein B in prostate cancer and its significance |
| Authors | Xiao Yun-bei Qiao Zheng-guo Zhang Xiao-wei Liu Zhen-hua Xie Jing Hao Yi-chang Yu Wei-dong Xu Tao Wang Xiao-feng |
| Affiliation | Department of Urology, Peking University People's Hospital, Beijing 100044, China. |
| Issue Date | 2011 |
| Publisher | 开云app体育 学报 医学版 |
| Citation | Beijing da xue xue bao. Yi xue ban.2011,43,(4),496-9. |
| Abstract | To investigate the expression of glycoprotein non-metastatic melanoma protein B (GPNMB) in prostate cancer and its clinical significance.The expression of GPNMB was analysed in 63 prostate cancer and 3 heterosexual hyperplasia prostate tissue and 8 benign prostatic hyperplasia samples by immunohistochemical staining, with integral optical density(IOD) value representing expression level of positive cells.The expression of GPNMB was lower in benign prostatic hyperplasia (BPH, IOD=70 017.49) than in Atypical hyperplasia (IOD=101 547.33, P=0.000 1) . The expression of GPNMB in tumor (IOD= 162 027.54) was higher than in non-tumor group (IOD=79 290.97), which included BPH and atypical hyperplasia (P=0.000 1). But GPNMB expression level was not positively elevated with degree of malignancy of prostate cancer. However, the expression of GPNMB in low pathological grading(IOD=177 944.30) was higher than that in high pathological grading(IOD=150 885.81, P=0.013).The abnormal expression of GPNMB may play an important role in the development of prostate cancer and its detection may be useful for the early diagnosis of prostate cancer. |
| URI | http://hdl.handle.net/20.500.11897/307318 |
| ISSN | 1671-167X |
| Indexed | PubMed |
| Appears in Collections: | 人民医院 |
