| Title | Overexpression and immunosuppressive functions of transforming growth factor 1, vascular endothelial growth factor and interleukin-10 in epithelial ovarian cancer |
| Authors | Liu, Chan-zhen Zhang, Li Chang, Xiao-hong Cheng, Ye-xia Cheng, Hong-yan Ye, Xue Fu, Tian-yun Chen, Jun Cui, Heng |
| Affiliation | Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China. |
| Keywords | Epithelial ovarian cancer Tumor microenvironment Immunosuppression Cytokines REGULATORY T-CELLS FACTOR EXPRESSION DENDRITIC CELLS LUNG-CANCER FACTOR-BETA CLINICOPATHOLOGICAL SIGNIFICANCE CARCINOMA PATIENTS POOR-PROGNOSIS GASTRIC-CANCER TGF-BETA |
| Issue Date | 2012 |
| Publisher | 中国癌症研究英文版 |
| Citation | CHINESE JOURNAL OF CANCER RESEARCH.2012,24,(2),130-137. |
| Abstract | Transforming growth factor-1 (TGF-beta 1), vascular endothelial growth factor (VEGF), and interleukin-10 (IL-10) may be critical cytokines in the microenvironment of a tumor, playing roles in immune suppression. This study was conducted to elucidate the roles and immunosuppressive functions of these cytokines in epithelial ovarian cancer (EOC). The expression levels of TGF-beta 1, VEGF and IL-10 in malignant tissue were evaluated by immune-histochemistry and compared with corresponding borderline, benign, and tumor-free tissues. Moreover, relationships among the levels of these cytokines and correlations between expression and the prognosis of EOC were analyzed by Pearson rank correlations and multi-factor Logistic regression. The roles of TGF-beta 1, VEGF, and IL-10 in the immunosuppressive microenvironment of ovarian cancer were studied through dendritic cell (DC) maturation and CD4+CD25+FoxP3+ Treg generation in vitro experiments. TGF-beta 1, VEGF, and IL-10 were expressed in 100%, 74.69%, and 54.96% of EOC patients, respectively. TGF-beta 1 was an independent prognostic factor for EOC. IL-10 was significantly co-expressed with VEGF. In vitro, VEGF and TGF-beta 1 strongly interfered with DC maturation and consequently led to immature DCs, which secreted high levels of IL-10 that accumulated around the tumor site. TGF-beta 1 and IL-10 induced Treg generation without antigen presentation in DCs. TGF-beta 1, VEGF and IL-10 play important roles in EOC and can lead to frequent immune evasion events. |
| URI | http://hdl.handle.net/20.500.11897/307174 |
| ISSN | 1000-9604 |
| DOI | 10.1007/s11670-012-0130-y |
| Indexed | SCI(E) PubMed 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 人民医院 |
