| Title | Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma |
| Authors | Xiong Gengyan Liu Jin Tang Qi Fan Yu Fang Dong Yang Kaiwei Xie Feng Zhang Min Zhang Lei Liu Libo Zhang Cuijian Yao Lin Yang Li Ci Weimin Zhao Wei Gong Yanqing He Qun Gong Kan He Zhisong Wang Gang Li Xuesong Guo Yinglu Zhou Liqun |
| Affiliation | Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China. |
| Keywords | epigenetic biomarkers,nomogram,oncological outcomes,predictive model,upper tract urothelial carcinoma |
| Issue Date | 2015 |
| Publisher | epigenomics uk |
| Citation | Epigenomics.2015,1-12. |
| Abstract | We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients.Using methylation-sensitive polymerase chain reaction, we examined ten genes promoter methylation status in 687 UTUC patients.A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery.Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs. |
| URI | http://hdl.handle.net/20.500.11897/303908 |
| ISSN | 1750-192X |
| DOI | 10.2217/epi.15.34 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 北京肿瘤医院 |
