| Title | 抗精神病药所致迟发性运动障碍患者血浆非酶抗氧化物浓度的变化 |
| Other Titles | Alterations of plasma non-enzyme antioxidants levels in chronic schizophrenic patients with tardive dyskinesia |
| Authors | 李艳丽 杨甫德 谭云龙 朱凤艳 王宁 陈松 王志仁 周东丰 |
| Affiliation | 100096,北京回龙观医院精神医学研究中心 开云app体育 第六医院 |
| Keywords | 抗精神病药 运动障碍,药物性 血浆 抗氧化剂 白蛋白类 胆红素 尿酸 Antipsychotic agents Dyskinesia,drug-induced Plasma Antioxidant Albumins Bilirubin Uric acid |
| Issue Date | 2012 |
| Publisher | 中华精神科杂志 |
| Citation | 中华精神科杂志.2012,45,(1),16-19. |
| Abstract | 目的 探讨抗精神病药所致迟发性运动障碍(TD)患者血浆非酶抗氧化物浓度变化与TD的关系.方法 分别运用阳性和阴性症状量表(PANSS)和异常不自主运动量表(AIMS)评定精神症状和TD严重程度；使用全自动生化仪测定TD组(60例)、非TD组(60例)和对照组(45名)血浆白蛋白(Alb)、胆红素(Bil)、尿酸(UA)浓度,采用方差分析比较3组间上述指标的差异；采用单因素非条件Logistic回归分析各项生化指标与TD患者临床特征间的关系.结果 与对照组[(46.8±3.4) g/L和(12.7 ±3.3) μmol/L]比较,TD组[(40.2±2.5) g/L、(9.2±2.1)μmol/L]和非TD组[(41.2±2.3) g/L、(10.2 ±3.1)μmol/L] Alb和Bil明显降低,差异有统计学意义(P均＜0.001)；TD组Alb浓度低于非TD组(P =0.033),Bil浓度差异趋于显著水平(P =0.052),UA浓度差异无统计学意义；TD组AIMS总分与Bil(r=-0.373,P=0.008)、阴性症状分(r=-0.262,P=0.044)显著相关.结论 非酶抗氧化物可能在TD的病生理机制中起一定作用. Objective To inv.estigate the plasma non-enzyme antioxidants levels in chronic schizophrenic patients with tardive dyskinesia ( TD).Methods The plasma levels of albumin ( Alb),bilirubin (Bil) and uric acid (UA) in schizophrenic patients with TD (TD group,n =60) and without TD ( non-TD group,n =60) and healthy volunteers ( control group,n =45 ) were assayed by using full automatic biochemical analysor. The plasma antioxidants levels were compared among three groups by one-way ANOVA.Psychopathological symptoms and severities of TD were assessed by using the Positive and Negative Symptom Scale(PANSS) and Abnormal Involuntary Movement Scale (AIMS) respectively,the relationships of the plasma antioxidants levels and the clinical traits of TD were analyzed.Results Plasma Alb and Bil in control group [ (46.8 ± 3.4) g/L,( 12.7 ± 3.3 ) μmol/L] were significantly higher than those in TD [ (40.2 ±2.5) g/L,(9.2 ± 2.1 ) μ mol/L] and non-TD [ (41.2 ± 2.3 ) g/L,( 10.2 ± 3.1 ) μmol/L]groups (all P ＜ 0.001 ),but there were no significant differences on plasma UA concentrations among the three groups ( F =1.42,P =0.234).There was significant difference on the Alb concentrations between the TD and non-TD group ( P =0.033 ),and trend significant difference on Bil levels ( P =0.052 ).In TD group,the total score of AIMS were negatively related with Bil concentrations (r =-0.373,P =0.008) and negative sub-score of PANSS (r =- 0.262,P =0.044).Conclusions The non-enzyme antioxidants might be involved in the pathophysiology of TD. |
| URI | http://hdl.handle.net/20.500.11897/285967 |
| ISSN | 1006-7884 |
| DOI | 10.3760/cma.j.issn.1006-7884.2012.01.007 |
| Indexed | 中文核心期刊要目总览(PKU) 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 第六医院 |
