| Title | Cr(VI) exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins |
| Authors | Qu, Qingshan Li, Xiaomei An, Feiyun Jia, Guang Liu, Lanzeng Watanabe-Meserve, Hiroko Koenig, Karen Cohen, Beverly Costa, Max Roy, Nirmal Zhong, Mianhua Chen, Lung Chi Liu, Suhua Yan, Lei |
| Affiliation | NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA. Cent S Univ, Sch Publ Hlth, Dept Toxicol, Changsha 410078, Hunan, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China. Jinan Municipal Ctr Dis Control & Prevent, Jinan 250013, Shandong, Peoples R China. NYU, Sch Med, Nelson Inst Environm Med, 57 Old Forge Rd, Tuxedo Pk, NY 10987 USA. |
| Keywords | HEXAVALENT CHROMIUM COMPOUNDS OCCUPATIONAL EXPOSURE URINARY CHROMIUM BAND-3 MEMPHIS WORKERS BLOOD MECHANISMS CHROMATE CARCINOGENICITY LYMPHOCYTES |
| Issue Date | 2008 |
| Publisher | biomarkers |
| Citation | BIOMARKERS.2008,13,(5),467-477. |
| Abstract | A total of 195 subjects, including 141 exposed workers and 54 farmers, were recruited in China to evaluate the usefulness of chromium (Cr) in erythrocytes as a biomarker of exposure to Cr(VI). The levels of Cr in red blood cells (RBC) were remarkably elevated even in a group of workers routinely exposed to Cr(VI) as low as 5-15 g m(-3) and showed a significant exposure-response trend over the exposure range from 0.002 to 1152 g m(-3) (p0.0001). Multiple linear regression analyses indicated that age and cigarette smoke were not associated with Cr in RBC. However, female subjects had lower Cr in RBC compared with their male counterparts for about the same exposure levels (p < 0.05). The genotypes of band III, which encodes for anion transport protein and may regulate CrO(4)(-2) across cell membranes, were also identified and included for analysis. The ratios of Cr in RBC to Cr(VI) exposure were higher in subjects with a wild genotype than in those who had heterozygous or homozygous variant alleles. However, the difference was not statistically significant probably due to the limited number of participating subjects. In addition, 15 of the 141 workers were selected for multiple exposure monitoring and blood sample collections to evaluate the inter- and intraindividual variations of Cr in RBC. Compared with the personal exposure levels, Cr in RBC had small intraindividual variations with a reliability coefficient of 0.88. The study suggests that Cr in RBC may serve as a sensitive and reliable biomarker for long-term exposure to Cr(VI). |
| URI | http://hdl.handle.net/20.500.11897/249086 |
| ISSN | 1354-750X |
| DOI | 10.1080/13547500802099574 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
