| Title | Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats |
| Authors | Zhu, Mo-Tao Feng, Wei-Yue Wang, Bing Wang, Tian-Cheng Gu, Yi-Qun Wang, Meng Wang, Yun Ouyang, Hong Zhao, Yu-Liang Chai, Zhi-Fang |
| Affiliation | Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Efffects Nanomat & Nanosafety, Beijing 100049, Peoples R China. Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China. Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China. Hosp Haidian Dist, Beijing 100080, Peoples R China. Peking Univ, Dept Clin Lab Med, Hosp 3, Beijing 100083, Peoples R China. |
| Keywords | ferric oxide nanoparticle pulmonary response coagulatory disturbance intratracheal instillation PARTICULATE AIR-POLLUTION LUNG EPITHELIAL-CELLS ULTRAFINE PARTICLES ENVIRONMENTAL-POLLUTANTS CARBON-NANOTUBES EXPOSURE TOXICITY HEALTH MICE IRON |
| Issue Date | 2008 |
| Publisher | toxicology |
| Citation | TOXICOLOGY.2008,247,(2-3),102-111. |
| Abstract | Ferric oxide (Fe(2)O(3)) nanoparticles are of considerable interest for application in nanotechnology related fields. However, as iron being a highly redox-active transition metal, the safety of iron nanomaterials need to be further studied. In this study, the size, dose and time dependent of Fe(2)O(3) nanoparticle on pulmonary and coagulation system have been studied after intratracheal instillation. The Fe(2)O(3) nanoparticles with mean diameters of 22 and 280 nm, respectively, were intratracheally instilled to male Sprague Dawley rats at low (0.8 mg/kg bw) and high (20 mg/kg bw) doses. The toxic effects were monitored in the post-instilled 1, 7 and 30 days. Our results showed that the Fe(2)O(3) nanoparticle exposure could induce oxidative stress in lung. Alveolar macrophage (AM) over-loading of phagocytosed nanoparticle by high dose treatment had occurred, while the non-phagocytosed particles were found entering into alveolar epithelial in day 1 after exposure. Several inflammatory reactions including inflammatory and immune cells increase, clinical pathological changes: follicular hyperplasia, protein effusion, pulmonary capillary vessel hyperaemia and alveolar lipoproteinosis in lung were observed. The sustain burden of particles in AM and epithelium cells has caused lung emphysema and pro-sign of lung fibrosis. At the post-instilled day 30, the typical coagulation parameters, prothrombin time (PT) and activated partial thromboplastin time (APTT) in blood of low dose 22 nm-Fe(2)O(3) treated rats were significantly longer than the controls. We concluded that both of the two-sized Fe(2)O(3) particle intratracheal exposure could induce lung injury. Comparing with the submicron-sized Fe(2)O(3) particle, the nano-sized Fe(2)O(3) particle may increase microvascular permeability and cell lysis in lung epitheliums and disturb blood coagulation parameters significantly. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/249000 |
| ISSN | 0300-483X |
| DOI | 10.1016/j.tox.2008.02.011 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
