| Title | Expression of LAPTM4B-35: A novel marker of progression, invasiveness and poor prognosis of extrahepatic cholanglocarcinoma |
| Authors | Zhou, Li He, Xiao-Dong Cui, Quan-Cai Zhou, Wei-Xun Qu, Qiang Zhou, Rou-Li Rui, Jing-An Yu, Jian-Chun |
| Affiliation | Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100032, Peoples R China. Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing 100032, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China. |
| Keywords | lysosome-associated protein transmembrane-4 beta extrahepatic cholangiocarcinoma survival resection BILE-DUCT CARCINOMA INTRAHEPATIC CHOLANGIOCARCINOMA CHOLANGIOCELLULAR CARCINOMA HEPATOCELLULAR-CARCINOMA SURGICAL-TREATMENT OVEREXPRESSION SURVIVAL RECURRENCE EXPERIENCE RESECTION |
| Issue Date | 2008 |
| Publisher | cancer letters |
| Citation | CANCER LETTERS.2008,264,(2),209-217. |
| Abstract | LAPTM4B was proven to overexpress in hepatocellular carcinoma and relate to differentiation. We immunohistochemically investigated the expression and potential clinicopathological and prognostic significance of LAPTM4B encoded protein, LAPTM4B-35, in extrahepatic cholangiocarcinoma (EHCC) for specimens from consecutive 81 patients. LAPTM4B-35 staining was positive in cancer tissues from 59 patients (72.8%), including 12 with score 1, 22 with score 2 and 25 with score 3. No positive staining was found in non-cancer epithelia. The staining score in cancer tissues was not only significantly associated with TNM staging, histological grade, perineural and lymph node invasion (P < 0.05), but also of comprehensive prognostic implications, including integrated estimation with CA19-9. These data established that LAPTM4B-35 positively expressed in a great portion of EHCC and might be a novel molecular maker of progression, invasiveness and poor prognosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/248884 |
| ISSN | 0304-3835 |
| DOI | 10.1016/j.canlet.2008.01.025 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
