| Title | Gelatin nanofibrous membrane fabricated by electrospinning of aqueous gelatin solution for guided tissue regeneration |
| Authors | Zhang, Shen Huang, Yaqin Yang, Xiaoping Mei, Fang Ma, Qi Chen, Guoqiang Ryu, Seungkon Deng, Xuliang |
| Affiliation | Beijing Inst Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China. Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China. Peking Univ, Hosp Stomatol, Beijing 100081, Peoples R China. Tsinghua Univ, Hosp 2, Dept Neurosurg, Beijing 100084, Peoples R China. Chungnam Natl Univ, Dept Chem Engn, Taejon 305764, South Korea. |
| Keywords | gelatin electrospinning crosslinking periodontal ligament cell PERIODONTAL-LIGAMENT ENGINEERING APPLICATIONS CROSS-LINKING RELEASE CELLS SCAFFOLD MATS |
| Issue Date | 2009 |
| Publisher | journal of biomedical materials research part a |
| Citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.2009,90A,(3),671-679. |
| Abstract | The electrospinning of gelatin aqueous Solution Was successfully carried Out by elevating the spinning temperature. The effects of spinning temperature and solution concentration were investigated on the morphology of gelatin nanofibers in the current study. To improve the stability and mechanical properties in moist state, the gelatin nanofibrous membrane was chemically crosslinked by 1-ethyl-3-dimethyl-aminopropyl carbodiimide hydrochloride and N-hydroxyl succinimide. The concentration of crosslinker was optimized by measuring the swelling degree and weight loss. Nanofibrous structure of the membrane was retained after lyophilization, although the fibers were curled and conglutinated. Tensile test revealed that the hydrated membrane becomes pliable and provides predetermined mechanical properties. Periodontal ligament cells cultured on the membrane in vitro exhibited (,good cell 0 attachment, growth, and proliferation. Gelatin nanofibrous membrane can be one of promising biomaterials for the regeneration of damaged periodontal tissues. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 671-679, 2009 |
| URI | http://hdl.handle.net/20.500.11897/247552 |
| ISSN | 1549-3296 |
| DOI | 10.1002/jbm.a.32136 |
| Indexed | SCI(E) |
| Appears in Collections: | 口腔医院 |
