| Title | Pulmonary function testing in patients with pulmonary arterial hypertension |
| Authors | Jing, Zhi-Cheng Xu, Xi-Qi Badesch, David B. Jiang, Xin Wu, Yan Liu, Jin-Ming Wang, Yong Pan, Lei Li, Hui-Ping Pu, Jie-Lin Zhang, Zhuo-Li Yang, Yue-Jin |
| Affiliation | Tongji Univ, Shanghai Pulm Hosp, Dept Pulm Circulat, Shanghai 200433, Peoples R China. Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100037, Peoples R China. Peking Union Med Coll, Beijing 100021, Peoples R China. Aviat Ind Cent Hosp, Beijing, Peoples R China. Univ Colorado, Hlth Sci Ctr, Boulder, CO 80309 USA. Peking Univ, Beijing Shijitan Hosp, Beijing 100871, Peoples R China. Peking Univ, Hosp 1, Beijing 100871, Peoples R China. Tongji Univ, Shanghai Pulm Hosp, Dept Pulm Circulat, 507 Zhengmin Rd, Shanghai 200433, Peoples R China. |
| Keywords | Airway obstruction Pulmonary arterial hypertension Pulmonary function test Pulmonary diffusion capacity OBSTRUCTION GUIDELINES EXPRESSION DIAGNOSIS LUNGS |
| Issue Date | 2009 |
| Publisher | 呼吸道医学 |
| Citation | RESPIRATORY MEDICINE.2009,103,(8),1136-1142. |
| Abstract | Background: Although previous studies have shown that peripheral airway obstruction can occur in idiopathic PAH (IPAH), pulmonary function tests have not been well-studied in patients with PAH associated with congenital heart disease (CHD-PAH) and connective tissue disease (CTD-PAH). Methods: A multicenter prospective study was performed in PAH patients in China. Pulmonary function tests were evaluated in 190 PAH patients. Results: Total lung capacity (TLC), residual volume (RV) and total airway resistance (Rtot) were similar in PAH patients and controls. However, measures of airflow, including vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s(FEV(1)), FEV(1)/FVC and MEF(50) were decreased in PAH group. Single-breath diffusion capacity for carbon monoxide (DL(CO)) was also decreased in PAH patients. Expiratory flow-volume curves showed reduction and a curvilinear appearance in patients with PAH. Similar changes were observed among the various subgroups of IPAH, CHD-PAH, and CTD-PAH patients. More CTD-PAH patients had abnormal DL(CO). Conclusions: Airway obstruction is common in IPAH, CHD-PAH and CTD-PAH patients. CTD-PAH patients have lower DL(CO). Hemodynamics, serum markers and exercise capacity parameters did not correlate well with pulmonary function indices. (C) 2009 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/246771 |
| ISSN | 0954-6111 |
| DOI | 10.1016/j.rmed.2009.03.009 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京世纪坛医院 第一医院 |
