| Title | Total Synthesis of (-)-5,6-Dihydrocineromycin B |
| Authors | Li, Guozhi Yang, Xiaoxia Zhai, Hongbin |
| Affiliation | Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synthet Organ Chem, Shanghai 200032, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China. Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synthet Organ Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China. |
| Keywords | ENANTIOSELECTIVE TOTAL-SYNTHESIS NATURAL-PRODUCTS REDUCTION ALCOHOLS |
| Issue Date | 2009 |
| Publisher | journal of organic chemistry |
| Citation | JOURNAL OF ORGANIC CHEMISTRY.2009,74,(3),1356-1359. |
| Abstract | An asymmetric total synthesis of (-)-5,6-dihydrocineromycin B has been accomplished in 13 steps from (-)-linalool O-triethylsilyl ether or 12 steps from geraniol. The present synthesis features (i) an intermolecular Wittig reaction involving an aldehyde possessing a ketophosphonate functionality and (ii) an intramolecular Horner-Wadsworth-Emmons olefination. |
| URI | http://hdl.handle.net/20.500.11897/246523 |
| ISSN | 0022-3263 |
| DOI | 10.1021/jo802503x |
| Indexed | SCI(E) EI |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
