| Title | Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats |
| Authors | Su, Rui-Bin Wang, Wei-Ping Lu, Xin-Qiang Wu, Ning Liu, Zhi-min Li, Jin |
| Affiliation | Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China. Peking Univ, Natl Inst Drug Dependence China, Beijing 100083, Peoples R China. Beijing Inst Pharmacol & Toxicol, TaiPing Rd 27, Beijing 100850, Peoples R China. |
| Keywords | Morphine Agmatine Drug self-administration NITRIC-OXIDE SYNTHASE SUBSTANCE DEPENDENCE ETHANOL WITHDRAWAL ADDICTION COCAINE INHIBITION TOLERANCE SEEKING STRESS HEROIN |
| Issue Date | 2009 |
| Publisher | pharmacology biochemistry and behavior |
| Citation | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR.2009,92,(4),676-682. |
| Abstract | Our previous studies showed that agmatine inhibits morphine-induced conditioned place preference, locomotor sensitization and drug discrimination in rats. in the present study, we investigated the effects of agmatine on intravenous morphine self-administration in rats. At a dose of 80 mg/kg/infusion, agmatine did not substitute for intravenous morphine (0.5 mg/kg/infusion) self-administration, suggesting that agmatine itself has no reinforcing effect. However, pretreatment with agmatine (40 or 80 mg/kg, i.g.) significantly inhibited the acquisition of intravenous morphine self-administration as assessed by the nose-poke response and morphine intake. The mean number of days required to meet the acquisition criteria for intravenous morphine self-administration was significantly prolonged. After acquisition of intravenous morphine self-administration, chronic administration of agmatine (40 or 80 mg/kg x 30 days, bid, i.g.) during the extinction period significantly prevented the re-acquisition of intravenous morphine self-administration. The ability of agmatine to inhibit the acquisition and re-acquisition of intravenous morphine self-administration suggests a possible use of agmatine in the treatment of opioid dependence. (c) 2009 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/245800 |
| ISSN | 0091-3057 |
| DOI | 10.1016/j.pbb.2009.03.009 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
