| Title | Assessing local determinants of neural tube defects in the Heshun Region, Shanxi Province, China |
| Authors | Wang, Jin-Feng Liu, Xin Christakos, George Liao, Yi-Lan Gu, Xue Zheng, Xiao-Ying |
| Affiliation | Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China. San Diego State Univ, Dept Geog, San Diego, CA 92182 USA. Beijing Inst Pediat, Beijing 100012, Peoples R China. Peking Univ, Inst Populat Sci, Beijing 100871, Peoples R China. |
| Keywords | BIRTH-DEFECTS HIGH-PREVALENCE PUBLIC-HEALTH RISK-FACTORS POPULATION AREA DEFICIENCY CHALLENGES RATES WATER |
| Issue Date | 2010 |
| Publisher | bmc public health |
| Citation | BMC PUBLIC HEALTH.2010,10. |
| Abstract | Background: Neural tube defect (NTD) prevalence in northern China is among the highest worldwide. Dealing with the NTD situation is ranked as the number one task in China's scientific development plan in population and health field for the next decade. Physical and social environments account for much of the disease's occurrence. The environmental determinants and their effects on NTD vary across geographical regions, whereas factors that play a significant role in NTD occurrence may be buried by global statistics analysis to a pooled dataset over the entire study area. This study aims at identification of the local determinants of NTD across the study area and exploration of the epidemiological implications of the findings. Methods: NTD prevalence rate is represented in terms of the random field theory, and Rushton's circle method is used to stabilize NTD rate estimation across the geographical area of interest; NTD determinants are represented by their measurable proxy variables and the geographical weighted regression (GWR) technique is used to represent the spatial heterogeneity of the NTD determinants. Results: Informative maps of the NTD rates and the statistically significant proxy variables are generated and rigorously assessed in quantitative terms. Conclusions: The NTD determinants in the study area are investigated and interpreted on the basis of the maps of the proxy variables and the relationships between the proxy variables and the NTD determinants. No single determinant was found to dominate the NTD occurrence in the study area. Villages where NTD rates are significantly linked to environmental determinants are identified (some places are more closely linked to certain environmental factors than others). The results improve current understanding of NTD spread in China and provide valuable information for adequate disease intervention planning. |
| URI | http://hdl.handle.net/20.500.11897/245431 |
| ISSN | 1471-2458 |
| DOI | 10.1186/1471-2458-10-52 |
| Indexed | SCI(E) |
| Appears in Collections: | 人口研究所 |
