| Title | Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting |
| Authors | Duan, Cunxian Zhang, Dianrui Wang, Feihu Zheng, Dandan Jia, Lejiao Feng, Feifei Liu, Yue Wang, Yancai Tian, Keli Wang, Fengshan Zhang, Qiang |
| Affiliation | Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China. Shandong Univ, Sch Med, Inst Biochem & Mol Biol, Jinan 250012, Peoples R China. Shandong Univ, Sch Pharmaceut Sci, Natl Glycoengn Res Ctr, Jinan 250012, Peoples R China. Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Peoples R China. |
| Keywords | Nanogels Chitosan N-isopropylacrylamide Tumor extracellular pH Oridonin DRUG-DELIVERY IN-VITRO N-ISOPROPYLACRYLAMIDE PH NANOPARTICLES MICELLES CHITOSAN HYDROGELS RELEASE VIVO |
| Issue Date | 2011 |
| Publisher | international journal of pharmaceutics |
| Citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS.2011,409,(1-2),252-259. |
| Abstract | The principle objective of this research was to develop and characterize pH-responsive and biocompatible nanogels as a tumor-targeting drug delivery system. The nanogels were self-assembled from chitosan-based copolymers, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAm). The copolymers were synthesized via free radical copolymerization and characterized for their chemical structure by FT-IR and (1)H NMR. These copolymers could be efficiently loaded with oridonin (ORI) and the characteristics of ORI-loaded nanogels were evaluated. Drug release researches indicated that the ORI-loaded nanogels displayed pH-dependent release behaviors. Based on MTT assay and cellular morphological analysis, the anti-tumor activity of ORI-loaded nanogels was higher at pH 6.5 than at pH 7.4. In conclusion, the obtained nanogels appeared to be of great promise in tumor extracellular pH targeting for ORI. (C) 2011 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/239696 |
| ISSN | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2011.02.050 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
