| Title | Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: A multicenter double-blinded randomized controlled trial |
| Authors | Wang, Yong-jun He, Li-qun Sun, Wei Lu, Ying Wang, Xiao-qin Zhang, Pei-qing Wei, Lian-bo Cao, Shi-li Yang, Ni-zhi Ma, Hong-zhen Gao, Jing Li, Ping Tao, Xiao-juan Yuan, Fa-huan Li, Jing Yao, Chen Liu, Xusheng |
| Affiliation | Zhejiang Univ Chinese Med, Hangzhou Hosp Tradit Chinese Med, Dept Nephrol, Hangzhou 310007, Zhejiang, Peoples R China. Shanghai Univ Chinese Med, Shuguang Hosp, Dept Nephrol, Shanghai, Peoples R China. Jiangshu Univ Chinese Med, Affiliated Hosp, Dept Nephrol, Nanjing, Jiangsu, Peoples R China. Hubei Hosp Tradit Chinese Med, Dept Nephrol, Wuhan, Hubei Province, Peoples R China. Heilongjiang Acad Tradit Chinese Med, Dept Nephrol, Harbin, Heilongjiang Pr, Peoples R China. So Med Univ, Affiliated Zhujiang Hosp, Dept Nephrol, Guangzhou, Guangdong, Peoples R China. Tianjin Univ Tradit Chinese Med, Hosp 1, Dept Nephrol, Tianjin, Peoples R China. Guangdong Hosp Tradit Chinese Med, Dept Nephrol, Guangzhou, Guangdong, Peoples R China. Zhejiang Hosp Tradit Chinese Med, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China. Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Nephrol, Beijing, Peoples R China. China Japan Friendship Hosp, Inst Clin Med Sci, Dept Pharmacol, Beijing, Peoples R China. Hangzhou Red Cross Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China. Third Mil Med Univ, Xinqiao Hosp, Dept Nephrol, Chongqing, Peoples R China. Peking Univ, Affiliated Hosp 1, Dept Stat, Beijing 100871, Peoples R China. |
| Keywords | Chronic kidney disease Traditional Chinese medicine Fangjihuangqi decoction Dangguibuxue decoction Xiayuxue decoction Tufuling decoction Chronic renal failure TGF-BETA-1-STIMULATED NRK-49F CELLS CHRONIC RENAL-INSUFFICIENCY IN-VITRO MATRIX SYNTHESIS DIABETIC-RATS ACID-B EMODIN NEPHROPATHY TETRANDRINE BENAZEPRIL |
| Issue Date | 2012 |
| Publisher | journal of ethnopharmacology |
| Citation | JOURNAL OF ETHNOPHARMACOLOGY.2012,139,(3),757-764. |
| Abstract | Ethnopharmacological relevance: Stage 3 is the key phase of chronic kidney disease. Traditional Chinese medicine (TCM) has been used for the treatment of chronic kidney disease. But a large sample trial is desirable. Materials and methods: A total of 578 Chinese patients with primary glomerulonephritis in CKD stage 3 were randomly assigned to three groups: patients received TCM (TCM group). benazepril (Ben group), TCM combined with benazepril (TCM + Ben group). Patients were followed up for 24 weeks. The primary endpoint was the time to the composite of 50% increased of serum creatinine, end stage renal disease or death. Results: eGFR in the TCM and the TCM + Ben group were improved (week 24 vs. baseline, P < 0.05) while eGFR in the Ben group was decreased (week 24 vs. baseline, P > 0.05). 24 h urinary protein excretion (UP) and urinary albumin/creatinine (UAlb/Cr) were decreased in the TCM + Ben (week 24 vs. baseline, P < 0.05) and the Ben group (week 24 vs. baseline. P> 0.05). UP and UAlb/Cr were increased in the TCM group to week 12, then were stable (week 24 vs. baseline, P < 0.05). The hemoglobin in the TCM group was also improved (week 24 vs. baseline, P < 0.05). The accumulative survival rate in the TCM + Ben group was higher than that in the TCM group and the Ben group (P = 0.044). Side effects in the TCM group were the lowest in these groups (P < 0.05). The patients with dry cough in the TCM + Ben group and the Ben group were increased as compared with the TCM group (P < 0.05). Hyperkalemia happened less frequently in the TCM group as compared with the other two groups (P = 0.052). Conclusions: For the patients with CKD stage 3, TCM can improve eGFR and hemoglobin with lower side effects. Benazepril significantly decreased the proteinuria. Chinese medicine integrated with benazepril can ameliorate renal function and decrease proteinuria synergistically. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/234576 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2011.12.009 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
