| Title | Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008 |
| Authors | Xu, Xiaohua Deng, Furong Guo, Xinbiao Lv, Peng Zhong, Mianhua Liu, Cuiqing Wang, Aixia Tzan, Kevin Jiang, Silis Y. Lippmann, Morton Rajagopalan, Sanjay Qu, Qingshan Chen, Lung-Chi Sun, Qinghua |
| Affiliation | NYU, Dept Environm Med, Sch Med, Tuxedo Pk, NY 10987 USA. Ohio State Univ, Div Environm Hlth Sci, Coll Publ Hlth, Columbus, OH 43210 USA. Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100871, Peoples R China. Hangzhou Normal Univ, Dept Physiol, Hangzhou, Zhejiang, Peoples R China. Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA. Ohio State Univ, Coll Med, Div Cardiol, Columbus, OH 43210 USA. |
| Keywords | Air pollution Inflammation PM2.5 LONG-TERM EXPOSURE INSULIN-RESISTANCE ADIPOSE-TISSUE ENDOTHELIAL DYSFUNCTION OBESITY DISEASE ACTIVATION POLLUTANTS GAMES MODEL |
| Issue Date | 2012 |
| Publisher | 毒理学快报 |
| Citation | TOXICOLOGY LETTERS.2012,212,(2),147-156. |
| Abstract | Many studies have linked ambient fine particulate matter (aerodynamic diameters less than 2.5 mu m. PM2.5) air pollution to increased morbidity and mortality of cardiovascular diseases in the general population, but the biologic mechanisms of these associations are yet to be elucidated. In this study, we aimed to evaluate the relationship between daily variations in exposure to PM2.5 and inflammatory responses in mice during and for 2 months after the Beijing Olympic Games. Male C57BL/6 mice were exposed to Beijing PM2.5 or filtered air (FA) in 2008 during the 2 months of Beijing Olympic and Paralympic Games, and for 2 months after the end of the Games. During the Games, circulating monocyte chemoattractant protein 1 and interleukin 6 were increased significantly in the PM2.5 exposure group, when compared with the FA control group, although there were no significant inter-group differences in tumor necrosis factor-alpha or interferon-gamma, or in macrophages, neutrophils or lymphocytes in the spleen or thymus between these 2 groups. However, macrophages were significantly increased in the lung and visceral fat with increasing PM2.5. After the Olympic Games, there were no significant PM2.5-associated differences for macrophages, neutrophils or lymphocytes in the thymus, but macrophages were significantly elevated in the lung, spleen, subcutaneous and visceral fat with increasing PM2.5, and the numbers of macrophages were even higher after than those during the Games. Moreover, the number of neutrophils was markedly higher in the spleen for the PPM2.5-exposed- than the FA-group. These data suggest that short-term increases in exposure to ambient PM2.5 leads to increased systemic inflammatory responses, primarily macrophages and neutrophils in'the lung, spleen, and visceral adipose tissue. Short-term air quality improvements were significantly associated with reduced overall inflammatory responses. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/232125 |
| ISSN | 0378-4274 |
| DOI | 10.1016/j.toxlet.2012.05.014 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
