| Title | Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin |
| Authors | Zheng, Dandan Duan, Cunxian Zhang, Dianrui Jia, Lejiao Liu, Guangpu Liu, Yue Wang, Feihu Li, Caiyun Guo, Hejian Zhang, Qiang |
| Affiliation | Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Shandong, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China. Shandong Univ, Dept Pharmaceut, Coll Pharm, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China. |
| Keywords | Galactosylated chitosan Nanoparticles Oridonin Tumor targeting GRAFTED-PEGYLATED-CHITOSAN TISSUE DISTRIBUTION ASIALOGLYCOPROTEIN RECEPTOR DRUG-DELIVERY HEPG2 CELLS NANOCAPSULES PACLITAXEL PHARMACOKINETICS PERMEABILITY ENHANCEMENT |
| Issue Date | 2012 |
| Publisher | international journal of pharmaceutics |
| Citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS.2012,436,(1-2),379-386. |
| Abstract | In this study, oridonin-loaded nanoparticles coated with galactosylated chitosan (ORI-GC-NP) were prepared for tumor targeting and their characteristics were evaluated for the morphologies, particle size and zeta potential. Oridonin-loaded nanoparticles (ORI-NP) without galactosylated chitosan were prepared as a control. The entrapment efficiency of ORI-GC-NP and ORI-NP were 72.15% and 85.31%, respectively. The in vitro drug release behavior from nanoparticles displayed biphasic drug release pattern with initial burst release and consequently sustained release. Next, the pharmacokinetics and tissue distribution of ORI-GC-NP, ORI-NP and ORI solution were carried out. Pharmacokinetic analysis showed that ORI-GC-NP and ORI-NP could prolong the drug plasma levels compared with ORI solution. Meanwhile, the distribution of ORI-GC-NP to liver was higher than that of ORI-NP and free drug. In conclusion, ORI-GC-NP, as a promising intravenous drug delivery system for ORI, could be developed as an alternative to the conventional ORI preparations. (c) 2012 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/229893 |
| ISSN | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2012.06.039 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
