| Title | Regulation and dysregulation of astrocyte activation and implications in tumor formation |
| Authors | Yang, Chunzhang Rahimpour, Shervin Yu, Albert C. H. Lonser, Russell R. Zhuang, Zhengping |
| Affiliation | NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci,Minist Educ,Neurosci Res Inst, Dept Neurobiol,Minist Publ Hlth,Key Lab Neurosci, Beijing 100871, Peoples R China. NINDS, Surg Neurol Branch, NIH, Bldg 10,Room 3D20, Bethesda, MD 20892 USA. |
| Keywords | Glia Astrocytoma Gliosis Brain tumor Tumorigenesis Central nervous system FIBRILLARY ACIDIC PROTEIN HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ENDOTHELIAL GROWTH-FACTOR GLIOBLASTOMA STEM-CELLS P2 PURINERGIC RECEPTORS CENTRAL-NERVOUS-SYSTEM SPINAL-CORD-INJURY NF-KAPPA-B REACTIVE ASTROCYTES BETA-CATENIN |
| Issue Date | 2013 |
| Publisher | cellular and molecular life sciences |
| Citation | CELLULAR AND MOLECULAR LIFE SCIENCES.2013,70,(22),4201-4211. |
| Abstract | Astrocytic activation is a cellular response to disturbances of the central nervous system (CNS). Recent advances in cellular and molecular biology have demonstrated the remarkable changes in molecular signaling, morphology, and metabolism that occur during astrocyte activation. Based on these studies, it has become clear that the astrocyte activation process is regulated by a variety of signaling pathways, which result in metabolic support, wound healing and scar formation. While normal astrocyte activation pathways drive homeostasis and/or repair in the CNS, dysregulation of these pathways can lead to astrocyte abnormalities, including glioma formation with similar phenotypes as reactive astrocytes. We review the principle pathways responsible for astrocytic activation, as well as their potential contribution to tumor formation in the CNS. |
| URI | http://hdl.handle.net/20.500.11897/224067 |
| ISSN | 1420-682X |
| DOI | 10.1007/s00018-013-1274-8 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
