| Title | HPIP is Upregulated in Liver Cancer and Promotes Hepatoma Cell Proliferation via Activation of G2/M Transition |
| Authors | Xu, Xiaojie Jiang, Chengying Wang, Shibin Tai, Yanhong Wang, Tao Kang, Lei Fan, Zhongyi Li, Shuyue Li, Ling Fu, Jing Liu, Jiahong Ji, Quanbo Wang, Xuan Wei, Lixin Ye, Qinong |
| Affiliation | Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China. Tianjin Med Univ Canc Inst & Hosp, Dept Breast Canc Pathol, Tianjin, Peoples R China. Tianjin Med Univ Canc Inst & Hosp, Res Lab, Tianjin, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Gen Surg, Beijing, Peoples R China. Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China. Beijing Inst Biotechnol, Dept Med Mol Biol, 27 Tai Ping Lu Rd, Beijing 100850, Peoples R China. |
| Keywords | hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein cell cycle liver cancer cell growth INTERACTING PROTEIN HPIP HEPATOCELLULAR-CARCINOMA CYCLIN B1 PROGNOSTIC IMPLICATIONS GENE-EXPRESSION APOPTOSIS P53 BIOMARKERS LEUKEMIA RECEPTOR |
| Issue Date | 2013 |
| Publisher | iubmb生命科学 |
| Citation | IUBMB LIFE.2013,65,(10),873-882. |
| Abstract | Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) has been shown to play a role in cancer development and progression. However, the detailed role of HPIP in cancer cell growth and the exact mechanism by which HPIP regulates cancer cell proliferation remains unclear. Here, we report that HPIP is overexpressed in most of 328 liver cancer patients and regulates hepatoma cell proliferation through G2/M checkpoint activation. HPIP increased anchorage-dependent and -independent growth of human liver cancer cell lines. The amino acid region 531-631 of HPIP was important for its modulation of liver cancer cell growth. The increased effects of HPIP on liver cancer cell proliferation were associated with activation of the G2/M cell-cycle concomitant with a marked increase of cyclin B1 and the inhibition of the negative G2/M phase regulator GADD45. HPIP knockdown dramatically suppressed the growth of HepG2 liver cancer cells in nude mice. These data highlight the important role of HPIP in liver cancer cell growth and suggest that HPIP may be a good target for liver cancer therapy. (c) 2013 IUBMB Life, 65(10):873-882, 2013 |
| URI | http://hdl.handle.net/20.500.11897/220560 |
| ISSN | 1521-6543 |
| DOI | 10.1002/iub.1202 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
