| Title | Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple microRNAs in lung cancer cells |
| Authors | Ye, Li-Ping Hu, Juan Liang, Li Zhang, Chun-yang |
| Affiliation | Chinese Acad Sci, Shenzhen Inst Adv Technol, Single Mol Detect & Imaging Lab, Guangzhou 518055, Guangdong, Peoples R China. Peking Univ, Hosp 3, Dept Tumor Chemotherapy & Radiat Sickness, Beijing 100191, Peoples R China. |
| Keywords | ROLLING-CIRCLE AMPLIFICATION ISOTHERMAL AMPLIFICATION ULTRASENSITIVE DETECTION MIRNA DETECTION NUCLEIC-ACIDS DNA DETECTION SERS PROTEIN SCATTERING OLIGONUCLEOTIDES |
| Issue Date | 2014 |
| Publisher | chemical communications |
| Citation | CHEMICAL COMMUNICATIONS.2014,50,(80),11883-11886. |
| Abstract | We develop circular exponential amplification reaction (EXPAR)-based surface-enhanced Raman spectroscopy (SERS) for simultaneous sensitive detection of multiple microRNAs in non-small cell lung cancer cells. This method possesses distinct advantages of excellent selectivity and high sensitivity with a detection limit of as low as 0.5 fM, which has improved by as much as 6 orders of magnitude as compared with the previously reported SERS-based direct assay. |
| URI | http://hdl.handle.net/20.500.11897/217313 |
| ISSN | 1359-7345 |
| DOI | 10.1039/c4cc05598e |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
