| Title | Synthesis and characterization of thermosensitive, star-shaped poly(epsilon-caprolactone)-block-Poly(N-isopropylacrylamide) with porphyrin-core for photodynamic therapy |
| Authors | Dai, Xiao-Hui Jin, Hua Yuan, Si-Song Pan, Jian-Ming Wang, Xiao-Hong Yan, Yong-Sheng Liu, Dong-Ming Sun, Lin |
| Affiliation | Jiangsu Univ, Sch Chem & Chem Technol, Dept Chem Engn, Zhenjiang 212013, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China. Jiangsu Univ, Hosp Affiliated, Zhenjiang 212013, Peoples R China. CSR Qingdao Sifang Co Ltd, Qingdao 266111, Shandong, Peoples R China. |
| Keywords | Thermosensitive RAFT Singlet oxygen Star-shaped PDT POLYMERIC MICELLES DRUG-DELIVERY CANCER WATER COPOLYMERS SHELL POLY(N-ISOPROPYLACRYLAMIDE) PHOTOSENSITIZER CYCLODEXTRIN FLUORESCENCE |
| Issue Date | 2014 |
| Citation | JOURNAL OF POLYMER RESEARCH.2014,21,(6). |
| Abstract | Thermosensitive, amphiphilic, star-shaped poly (epsilon-caprolactone)-block-poly (N-isopropylacrylamide) with prophyrin-core (SPPCL-b-PNIPAAm) was synthesized by ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT) and characterized by NMR, IR, GPC in this study. The optical transmittance results showed that the lower critical solution temperatures (LCST) of the copolymer solutions were attractively close to normal physiologic temperature at around 37 A degrees C. Due to its amphiphilic property, the obtained SPPCL-b-PNIPAAm had a low critical micelle concentration (CMC) in an aqueous solution and self-assembled into micelles in water. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis of micelle morphology revealed a well-defined spherical shape with a diameter of around 100 nm. Moreover, SPPCL-b-PNIPAAm micelles obtained high singlet oxygen quantum yields and indicated a sensitivity to temperature, suggesting that the SPPCL-b-PNIPAAm was a stimulus-responsive photosensitizer which had a potential application in targeted photodynamic therapy. |
| URI | http://hdl.handle.net/20.500.11897/214378 |
| ISSN | 1022-9760 |
| DOI | 10.1007/s10965-014-0412-9 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 天然药物与仿生药物国家重点实验室 |
