| Title | Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs |
| Authors | Yang, Jing Dong, Chen Dong, Yafei Liu, Shi Pan, Linqiang Zhang, Cheng |
| Affiliation | North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China. Shannxi Normal Univ, Coll Life Sci, Xian 710062, Peoples R China. Peking Univ, Key Lab High Confidence Software Technol, Minist Educ, Inst Software,Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China. Huazhong Univ Sci & Technol, Sch Automat, Key Lab Image Informat Proc & Intelligent Control, Wuhan 430074, Peoples R China. |
| Keywords | fluorescent beacon binding-induced strand displacement DNA self-assembly gold nanoparticle logical computing DNA STRAND DISPLACEMENT G-QUADRUPLEX DNAZYME COMPUTATION CIRCUITS GATES NANOSTRUCTURES CASCADES SENSORS |
| Issue Date | 2014 |
| Publisher | acs applied materials interfaces |
| Citation | ACS APPLIED MATERIALS & INTERFACES.2014,6,(16),14486-14492. |
| Abstract | Recently, the toehold-mediated DNA strand displacement reaction has been widely used in detecting molecular signals. However, traditional strand displacement, without cooperative signaling among DNA inputs, is insufficient for the design of more complicated nanodevices. In this work, a logic computing system is established using the cooperative "binding-induced" mechanism, based on the AuNP-based beacons, in which five kinds of multiple-input logic gates have been constructed. This system can recognize DNA and protein streptavidin simultaneously. Finally, the manipulations of the logic system are also demonstrated by controlling programmed conjugate DNA/AuNP clusters. This study provides the possibility of detecting multiple input signals and designing complex nanodevices that can be potentially applied to the detection of multiple molecular targets and the construction of large-scale DNA-based computation. |
| URI | http://hdl.handle.net/20.500.11897/209831 |
| ISSN | 1944-8244 |
| DOI | 10.1021/am5036994 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 信息科学技术学院 高可信软件技术教育部重点实验室 |
