| Title | Functional polymorphisms of caveolin-1 variants as potential biomarkers of esophageal squamous cell carcinoma |
| Authors | Wang, Shanshan Zhang, Chuanzhen Liu, Ying Xu, Changqing Chen, Ziping |
| Affiliation | Shandong Univ, Qianfoshan Hosp, Dept Gastroenterol, Jinan 250014, Shandong, Peoples R China. Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Lab Genet,Sch Oncol, Beijing 100871, Peoples R China. Shandong Univ, Qianfoshan Hosp, Dept Gastroenterol, 66 JingShi Rd, Jinan 250014, Shandong, Peoples R China. |
| Keywords | Caveolin-1 esophageal squamous cell carcinoma polymerase chain reaction and restriction fragment length polymorphism single nucleotide polymorphism PROSTATE-CANCER CELLS BREAST-CANCER HAPLOTYPE RECONSTRUCTION PROGNOSTIC MARKER TUMOR PROGRESSION POOR-PROGNOSIS EXPRESSION GROWTH OVEREXPRESSION ASSOCIATION |
| Issue Date | 2014 |
| Publisher | biomarkers |
| Citation | BIOMARKERS.2014,19,(8),652-659. |
| Abstract | Objective: To investigate the association of caveolin-1 (CAV1) genetic variants (C239A (rs1997623), G14713A (rs3807987), G21985A (rs12672038), T29107A (rs7804372)) with esophageal squamous cell carcinoma (ESCC) susceptibility. Methods: A total of 427 patients with ESCC and 427 healthy controls were genotyped using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. Results: There were significant differences between patients and controls in distributions of their genotypes and allelic frequencies in G14713A and T29107A polymorphisms. Furthermore, haplotype analysis revealed that haplotypes CAAT and CAGT were associated with high risk for ESCC, while haplotype CGGA was protective against ESCC. Stratified analysis showed the associations between the SNPs (G14713A and T29107A) and ESCC risk were noteworthy among female patients and patients who never smoke or drank alcohol. Conclusions: Genetic polymorphisms of CAV1 G14713A and T29107A might affect an individual's susceptibility in developing ESCC, making them efficient potential genetic biomarkers for early detection of ESCC. |
| URI | http://hdl.handle.net/20.500.11897/207437 |
| ISSN | 1354-750X |
| DOI | 10.3109/1354750X.2014.968210 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
