| Title | The association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility: a meta-analysis based on case-control studies |
| Authors | Zhou, Xue Wei, Li Jiao, Guangjun Gao, Wei Ying, Mingzhen Wang, Ning Wang, Yajie Liu, Chuan |
| Affiliation | Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Obstet & Gynecol, Shanghai 200030, Peoples R China. Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai 200433, Peoples R China. PLA, Hosp 401, Dept Oncol, Qingdao, Shangdong, Peoples R China. Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China. PLA, Hosp 184, Dept Orthopaed, Yingtan, Jiangxi, Peoples R China. Second Mil Med Univ, Changhai Hosp, Dept Oncol, 168 Changhai Rd, Shanghai 200433, Peoples R China. |
| Keywords | Meta-analysis APE1 Asp148Glu Prostate cancer DNA-REPAIR GENES ACID SUBSTITUTION VARIANTS NORTH INDIAN POPULATION RISK ENDONUCLEASE-1 LOCALIZATION STATISTICS APE1/REF-1 EXCISION IMPACT |
| Issue Date | 2015 |
| Publisher | molecular genetics and genomics |
| Citation | MOLECULAR GENETICS AND GENOMICS.2015,290,(1),281-288. |
| Abstract | The apurinic/apyrimidinic endonuclease 1 (APE1) plays important roles in the repair of DNA damage and adducts. However, previous case-control studies on the association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility have shown contradictory results, this meta-analysis was performed to draw a more precise estimation of the relationship. A total of seven case-control studies including 1,294 cases and 1,762 controls were included for analysis. In overall, no significant associations were found in all genetic models (GG vs. TT: OR = 1.16, 95 % CI 0.89-1.52; TG vs. TT: OR = 1.04, 95 % CI 0.81-1.35; the dominant model GG + TG vs. TT: OR = 1.12, 95 % CI 0.96-1.30; the recessive model GG vs. TG + TT: OR = 0.90, 95 % CI 0.77-1.04); in the subgroup by source of control, we found a significant association for the dominant model in Hospital-based subgroup (OR = 1.34, 95 % CI 1.08-1.68), no significant associations were found in other models in the subgroups. This meta-analysis suggested that the APE1 Asp148Glu polymorphism was a risk factor for prostate cancer susceptibility in Hospital-based population. |
| URI | http://hdl.handle.net/20.500.11897/206182 |
| ISSN | 1617-4615 |
| DOI | 10.1007/s00438-014-0916-3 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
