| Title | Alterations of the daily rhythms of HPT axis induced by chronic unpredicted mild stress in rats |
| Authors | Guo, Tian-You Liu, Li-Jing Xu, Ling-Zhi Zhang, Ji-Chun Li, Su-Xia Chen, Cheng He, Li-Guo Chen, Yu-Ming Yang, Han-Dan Lu, Lin Hashimoto, Kenji |
| Affiliation | Shenzhen Univ, Dept Psychol, Normal Coll, Shenzhen 518060, Peoples R China. Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China. Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba 2608670, Japan. Chiba Univ, Grad Sch Med, Dept Anat & Dev Biol, Chiba 2608670, Japan. Peking Univ, Natl Inst Drug Dependence, 38 Xue Yuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Chronic unpredictable mild stress Depression HPT axis Daily rhythm THYROTROPIN-RELEASING-HORMONE PITUITARY-THYROID AXIS THYROXINE-BINDING GLOBULIN ANTIDEPRESSANT TREATMENT SUBCLINICAL HYPOTHYROIDISM IMMOBILIZATION STRESS PSYCHIATRIC-PATIENTS DEPRESSION TRIIODOTHYRONINE DISORDER |
| Issue Date | 2015 |
| Publisher | endocrine |
| Citation | ENDOCRINE.2015,48,(2),637-643. |
| Abstract | The relationship between thyroid function and depression has long been recognized. Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. However, the daily rhythm alteration of the functions of the hypothalamus pituitary thyroid axis (HPT) is uncertain. In the present study, we investigated the effects of chronic unpredictable mild stress (CUMS) on the daily rhythm alterations of triiodothyronine (T3), thyroxine (T4), and Thyroid Stimulating Hormone (TSH) in the plasma. We found that CUMS led to depressive-like behavior and the daily rhythm of T3, T4, and TSH in the plasma being disturbed, as well the plasma levels of T3 and T4 decreased compared to control group. Our findings indicate that CUMS not only induce hypofunction of HPT axis but also the disturbance of daily rhythm of PHT axis in rats. |
| URI | http://hdl.handle.net/20.500.11897/206092 |
| ISSN | 1355-008X |
| DOI | 10.1007/s12020-014-0314-y |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
