| Title | Abnormalities of structural covariance networks in drug-naive boys with attention deficit hyperactivity disorder |
| Authors | Li, Xinwei Cao, Qingjiu Pu, Fang Li, Deyu Fan, Yubo An, Li Wang, Peng Wu, Zhaomin Sun, Li Li, Shuyu Wang, Yufeng |
| Affiliation | Beihang Univ, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R China. Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China. Peking Univ Sixth Hosp, Beijing 100191, Peoples R China. Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China. Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China. |
| Keywords | ADHD SCN Orbito-trontal cortex Insula DEFICIT/HYPERACTIVITY DISORDER FUNCTIONAL CONNECTIVITY MR-IMAGES BRAIN CHILDREN CORTEX ADHD METAANALYSIS TASK ADOLESCENTS |
| Issue Date | 2015 |
| Publisher | psychiatry research neuroimaging |
| Citation | PSYCHIATRY RESEARCH-NEUROIMAGING.2015,231,(3),273-278. |
| Abstract | The aim of this study is to investigate whether the anatomical organization of large-scale brain systems would change in ADHD patients compared to healthy controls. We utilized a structural covariance network (SCN) mapping approach to investigate large-scale networks in 30 drug naive ADHD boys and 30 gender- and age-matched controls. The regions showing significant between-group differences in gray matter (GM) volume were defined as seed regions of interest. Then, the SCNs derived from these seeds were statistically compared between ADHD and controls. Significant regional GM volume decreases (P < 0.05, corrected) were observed in the right insula and the right orbito-frontal cortex (OFC) in ADHD relative to controls. Both SCNs derived from these two seeds showed more localized topology in ADHD group. Furthermore, significantly decreased structural connectivity were found between insula and right hippocampus, bilateral olfactory cortex, and between OFC and bilateral caudate nucleus (P < 0.05, corrected) in ADHD group. Significantly increased association was observed between insula and left middle temporal gyrus (P < 0.05, corrected) in ADHD group. Taken together, our results reveal abnormal regional brain anatomy as well as aberrant structural covariance networks in ADHD, supporting previous findings of dysfunction in distributed network organization in patients with ADHD. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/206050 |
| ISSN | 0925-4927 |
| DOI | 10.1016/j.psychresns.2015.01.006 |
| Indexed | SCI(E) |
| Appears in Collections: | 第六医院 |
