| Title | Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population |
| Authors | Wu, Suping Yue, Weihua Jia, Meixiang Ruan, Yan Lu, Tianlan Gong, Xiaohong Shuang, Mei Liu, Jing Yang, Xiaoling Zhang, Dai |
| Affiliation | Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China. Peking Univ, Inst Mental Hlth, 51,Hua Yuan Bei Rd, Beijing 100083, Peoples R China. |
| Keywords | single nucleotide polymorphism (SNP) transmission disequilibrium test (TDT) haplotype RECEPTOR SUBUNIT GENES GENOMEWIDE SCREEN DISORDER LINKAGE 7Q |
| Issue Date | 2007 |
| Publisher | american journal of medical genetics part b neuropsychiatric genetics |
| Citation | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS.2007,144B,(4),492-495. |
| Abstract | Autism is a pervasive neurodevelopmental disorder, with a significant role of genetic factors in its development. The neuropilin-2 (NRP2) gene is localized to 2q34, an autism susceptibility locus. NRP2 has been demonstrated to both guide axons and to control neuronal migration in the central nervous system. It has been reported that NRP2 may be required in vivo for sorting migrating cortical and striatal interneurons to their correct destination. We examine the association between the NRP2 gene and autism using a cohort of 169 Chinese Han family trios. Four single nucleotide polymorphisms (SNPs) were genotyped by the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analyses. The transmission disequilibrium. tests (TDT) of SNPs and haplotype association were carried out using the TDTPHASE program. We found significant genetic association between autism and two of the SNPs of the NRP2 gene (rs849578: P = 0.017, rs849563: P = 0.027), as well as specific haplotypes, especially those formed by rs849563. Furthermore, haplotypes constructed with all markers showed significant excess transmission in both global and individual haplotype analyses (P=0.004 and 0.017, respectively). The polymorphisms in the NR.P2 gene are associated with autism, implying that the NRP2 gene may render individuals to be predisposed to autism. (c) 2007 Wiley-Liss, Inc. |
| URI | http://hdl.handle.net/20.500.11897/198436 |
| ISSN | 1552-4841 |
| DOI | 10.1002/ajmg.b.30495 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第六医院 |
