| Title | Effect of milk on the 7,12-dimethylbenz[a]-anthracene-induced mammary tumor model in rat |
| Authors | Zhou, Hong Qin, Li-Qiang Tang, Fu-Lei Ma, De-Fu Wang, Pei-Yu Wang, Yan |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100083, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100083, Peoples R China. Soochow Univ, Sch Radiol & Publ Hlth, Dept Nutr & Food Hyg, Suzhou 215123, Peoples R China. Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China. |
| Keywords | mammary tumor milk 7,12-dimethylbenz(a)anthracene (DMBA) estrogen progesterone BREAST-CANCER RISK POSTMENOPAUSAL WOMEN VITAMIN-D OVARIECTOMIZED RATS DAIRY-PRODUCTS PROGESTERONE CONSUMPTION ESTROGEN CALCIUM FAT |
| Issue Date | 2007 |
| Publisher | 食品与化学品毒理学 |
| Citation | FOOD AND CHEMICAL TOXICOLOGY.2007,45,(10),1868-1872. |
| Abstract | Milk may be one of the risk factors in the development of breast cancer from epidemiological investigations. Our study investigated the hormones and main ingredients in milk and assessed the effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats by comparing differences among three groups: commercial milk (C), traditional milk (T) or water (W). During the 20-weeks experiment the C and T groups showed higher incidences of mammary tumors than the W group. After excluding potential confounding factors including fat and calcium, the C group was found to score higher than the T group in the indices of tumorigenesis. These findings suggested that DMBA-induced mammary tumors are more prevalent in milk-fed groups due in part to the contribution of estrogen and progesterone in milk. (c) 2007 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/198331 |
| ISSN | 0278-6915 |
| DOI | 10.1016/j.fct.2007.03.020 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 第六医院 |
