| Title | Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats |
| Authors | Ma, De-Fu Katoh, Ryohei Zhou, Hong Wang, Pei-Yu |
| Affiliation | Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Human Pathol, Yamanashi 4093898, Japan. Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100083, Peoples R China. Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Human Pathol, 1110 Shimokato, Yamanashi 4093898, Japan. |
| Keywords | mammary tumor milk smooth muscle actin proliferating cell nuclear antigen estrogen receptor BREAST-CANCER DAIRY-PRODUCTS RISK CARCINOMA ESTROGEN COWS FAT PROGESTERONE NUTRIENTS HORMONES |
| Issue Date | 2007 |
| Citation | ACTA HISTOCHEMICA ET CYTOCHEMICA.2007,40,(2),61-67. |
| Abstract | To assess the effect of milk on the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced mammary tumors, 48 female Sprague-Dawley rats treated with DMBA were divided into 3 groups and given 1 of 3 test solutions for 20 weeks as their drinking liquid: milk, estrone sulfate solution or tap water. The milk group showed a significantly great incidence (75%) in tumor development compared with the water group (38%) and was comparable to the estrone sulfate group (69%). Mean tumor number per rat in the milk group was significantly higher than that in the water group (p=0.009). We classified the mammary tumors into three histological types: intraductal papilloma, fibroadenoma, and adenocarcinoma. Although the percent of intraductal papilloma and fibroadenoma was almost same among the three groups, malignant tumor was found only in the milk and estrone sulfate groups. In conclusion, our results indicate that milk as well as estrone sulfate promotes the development of DMBA-induced mammary tumors in rat and could be associated with the occurrence of adenocarcinoma. |
| URI | http://hdl.handle.net/20.500.11897/198298 |
| ISSN | 0044-5991 |
| DOI | 10.1267/ahc.07008 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
