| Title | Higher rates of t(11;18) in Chinese patients with transformed type of MALT lymphoma suggest novel pathways for progression of the disease |
| Authors | Ke, Xiaoyan Zhao, Linzhi Gao, Zifen Wang, Jing Dong, Fei Zhou, Xiaoge Shi, Lin Huang, Xuebiao Jing, Hongmei Wang, Jijun Zhao, Wei Yang, Xiao-Feng |
| Affiliation | Peking Univ, Third Hosp, Dept Hematol, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China. Peking Univ, Third Hosp, Lymphoma Res Ctr, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China. Peking Univ, Third Hosp, Dept Pathol, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China. Beijing Youyi Hos, Dept Pathol, Beijing, Peoples R China. Peking Univ, Third Hosp, Dept Gastroenterol Dis, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China. Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19122 USA. |
| Keywords | MALT lymphoma chromosomal translocation t(11 18) BCL-10 expression Chinese patients anti-H.-pylori therapy B-CELL LYMPHOMA HELICOBACTER-PYLORI TISSUE LYMPHOMA BCL10 GENE T(11/18)(Q21,Q21) T(1/14)(P22,Q32) CLASSIFICATION TRANSLOCATION ERADICATION |
| Issue Date | 2007 |
| Publisher | leukemia lymphoma |
| Citation | LEUKEMIA & LYMPHOMA.2007,48,(11),2157-2166. |
| Abstract | To detect the t(11; 18) chromosome translocation in different stages of mucosa-associated lymphoid tissue (MALT) lymphoma, we established a RT-PCR method by adopting three new primer pairs and using the RNA extracted from the paraffin tissues to amplify the t(11; 18) fusion gene API2-MALT1 in shorter lengths. Our results showed five key findings, which are (a) higher detection rates of t(11; 18) (21.13%) in Chinese patients with transformed MALT lymphoma, (b) lower detection rates of t(11; 18) in stomach MALT lymphoma, (c) different organ localizations of MALT lymphoma in Chinese patients, (d) higher nuclear expression rates of Bcl-10 in low grade MALT (51.72%), and (e) lower response rates (50% CR, and 50% PR) to anti -H.-pylori therapy. These findings suggest novel pathways for low-grade MALT lymphoma to be progressed into transformed MALT lymphoma. This study also suggests that amplification of shorter length of PCR products from the paraffin-fixed tissues increases sensitivity, which is significant in improving the selection of the therapeutic regimen and assessing the prognosis of the disease. |
| URI | http://hdl.handle.net/20.500.11897/198094 |
| ISSN | 1042-8194 |
| DOI | 10.1080/10428190701606818 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 |
