| Title | Ce-wts-1 plays important roles in Caenorhabditis elegans development |
| Authors | Cai, Qingchun Wang, Wenqing Gao, Ying Yang, Yongfei Zhu, Zuoyan Fan, Qichang |
| Affiliation | Peking Univ, Sch Life Sci, Coll Life Sci, Beijing 100871, Peoples R China. Peking Univ, Sch Life Sci, Coll Life Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| Keywords | Warts family Ce-wts-1 TGF-beta Development Membrane Caenorhabditis elegans REGULATES BODY-SIZE C-ELEGANS HOMEODOMAIN PROTEIN SIGNALING PATHWAY LIFE-SPAN KINASE HOMOLOG ENCODES GROWTH PHOSPHORYLATION |
| Issue Date | 2009 |
| Publisher | 欧洲生化学会联合会快报 |
| Citation | FEBS LETTERS.2009,583,(19),3158-3164. |
| Abstract | The Hippo-Warts pathway defines a novel signaling cascade involved in organ size control and tumor suppression. However, the developmental function of this pathway is less understood. Here we report that the Caenorhabditis elegans homolog of Warts, Ce-wts-1, plays important roles during worm development. The null allele of Ce-wts-1 causes L1 lethality. Partial loss of Ce-wts-1 function by RNAi reveals that Ce-wts-1 is involved in many developmental processes such as larval development, growth rate regulation, gut granule formation, pharynx development, dauer formation, life-span and body length control. Genetic analyses show that Ce-wts-1 functions synergistically with the TGF-beta Sma/Mab pathway to regulate body length. In addition, CE-WTS-1::GFP is enriched near the inner cell membrane, implying its possible membrane-related function. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/196730 |
| ISSN | 0014-5793 |
| DOI | 10.1016/j.febslet.2009.09.002 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 生命科学学院 |
