| Title | Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons |
| Authors | Wang, Rui Li, Yu-Hua Xu, Ying Li, Ying-Bo Wu, Hong-Li Guo, Hao Zhang, Jian-Zhao Zhang, Jing-Jie Pan, Xue-Yang Li, Xue-Jun |
| Affiliation | Peking Univ, Dept Pharmacol, Sch Basic Med Sci, State Key Lab Nat Biomimet Drugs, Beijing 100083, Peoples R China. Cornell Univ, Dept Pharmacol, Weill Med Coll, New York, NY 10021 USA. Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA. Univ Florida, Evelyn F & William L Mcknight Brain Inst, Gainesville, FL USA. |
| Keywords | BDNF Curcumin MAPK PI-3K TrkB FAMILY TRANSCRIPTION FACTOR ANTIDEPRESSANT DRUGS HIPPOCAMPAL-NEURONS SIGNALING PATHWAYS TYROSINE KINASE RAT HIPPOCAMPUS PROTEIN-KINASE MESSENGER-RNA BDNF CREB |
| Issue Date | 2010 |
| Publisher | 神经与精神药理学和生物精神病学进展 |
| Citation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY.2010,34,(1),147-153. |
| Abstract | Curcumin is a major constituent of curcuma longa, a traditional medicine used to manage mental disorders effectively in China. The neuroprotective effects of curcumin have been demonstrated in our previous studies. In the present research, we confirmed this effect by showing that curcumin application promoted the viability of cultured rodent cortical neurons. Moreover, when neurons were pretreated with tyrosine kinase B (TrkB) antibody, known to inhibit the activity of brain-derived neurotrophic factor (BDNF), the protective effect of curcumin was blocked. Additionally, treatment of curcumin increased BDNF and phosphor-TrkB and both of these enhancements can be suppressed by ERK and PI-3K inhibitors. The administration of curcumin led to increased levels of phosphor-ERK and AKT, which were each blocked by MAPK and PI-3K inhibitors. Furthermore, the curcumin-induced increase in phosphorylated cyclic AMP response element binding protein (CREB), which has been implicated as a possible mediator of antidepressant actions, was prevented by MAPK and PI-3K inhibitors. Therefore, we hypothesize the neuroprotection of curcumin might be mediated via BDNF/TrkB-MAPK/PI-3K-CREB signaling pathway. (C) 2009 Published by Elsevier Inc. |
| URI | http://hdl.handle.net/20.500.11897/196578 |
| ISSN | 0278-5846 |
| DOI | 10.1016/j.pnpbp.2009.10.016 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
