| Title | Double measurements of serum HCG concentration and its ratio may predict IVF outcome |
| Authors | Chi, Hongbin Qiao, Jie Li, Hongzhen Liu, Ping Ma, Caihong |
| Affiliation | Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, Beijing 100191, Peoples R China. Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, 49 N Garden Rd, Beijing 100191, Peoples R China. |
| Keywords | human chorionic gonadotrophin IVF outcome pregnancy ratio HUMAN CHORIONIC-GONADOTROPIN IN-VITRO FERTILIZATION HETEROTOPIC PREGNANCY ECTOPIC PREGNANCY EMBRYO-TRANSFER ASSISTED REPRODUCTION RISK-FACTORS IMPLANTATION MULTIPLE CONCEPTION |
| Issue Date | 2010 |
| Publisher | reproductive biomedicine online |
| Citation | REPRODUCTIVE BIOMEDICINE ONLINE.2010,20,(4),504-509. |
| Abstract | Serum human chorionic gonadotrophin (HCG) concentration is nearly always used to predict pregnancy but there is little data on the clinical utility of the ratio of HCG(21)/HCG(14) combined with double measurement of serum HCG. A total of 1762 cycles were retrospectively analysed for serum HCG concentration and ratio of HCG(21)/HCG(14) on days 14 and 21 after embryo transfer to determine whether the ratio combined with concentration is the optimal predictor of pregnancy. The medians of HCG concentration on days 14 and 21 combined with the ratio of HCG(21)/HCG(14) were calculated for non-viable, viable and heterotopic pregnancies. HCG concentrations of 290 IU/l on day 14 and 2970 IU/l on day 21 were regarded as the cut-off values to predict viable pregnancy, and values of 630 and 12,000 IU/l, respectively, were regarded as the cut-off values to predict multiple pregnancy. The ratio of HCG(21)/HCG(14) in the viable pregnancy group was significantly higher than that in the non-viable pregnancy group (15.86 versus 5.27, P < 0.0001). For heterotopic pregnancy, the ratio of HCG(21)/HCG(14) was 11.93. It was concluded that HCG concentration on days 14 and 21 combined with the ratio of HCG(21)/HCG(14) provides a useful predictor of pregnancy outcome. A ratio >15 may predict viable pregnancy. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/195930 |
| ISSN | 1472-6483 |
| DOI | 10.1016/j.rbmo.2010.01.005 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 |
