| Title | Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice |
| Authors | Yang, Ruiyue Pei, Xinrong Wang, Junbo Zhang, Zhaofeng Zhao, Haifeng Li, Qiong Zhao, Ming Li, Yong |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China. Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China. Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China. Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing 100069, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | bioactive peptide radioprotective immunosuppression T-cell subpopulation cytokine nuclear factor kappa B BONE-MARROW-CELLS FACTOR-KAPPA-B IONIZING-RADIATION BIOACTIVE PEPTIDES ULTRAVIOLET-RADIATION CYTOKINE FOOD EXPRESSION RESPONSES RECOVERY |
| Issue Date | 2010 |
| Publisher | 食品科学与农业杂志 |
| Citation | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE.2010,90,(13),2241-2248. |
| Abstract | BACKGROUND: A marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to enhance the innate and adaptive immunities through stimulation of the secretion of cytokines in mice. The current study aimed to further investigate the protective effect of MOP on radiation-induced immune suppression in mice. RESULTS: Female ICR mice (6-8 weeks old) were randomly divided into three groups, i.e. blank control, irradiation control and MOP(1.350 g kg(-1) body weight) plus irradiation-treated group. MOP significantly increased the survival rate and prolonged the survival times for 30 days after irradiation, and lessened the radiation-induced suppression of T-or B-lymphocyte proliferation, resulting in the recovery of cell-mediated and humoral immune functions. This effect may be produced by augmentation of the relative numbers of radioresistant CD(4)(+) T cells, enhancement of the level of immunostimulatory cytokine, IL-12, reduction of the level of total cellular NF-kappa B through the induction of I kappa B in spleen and inhibition of the apoptosis of splenocytes. CONCLUSION: We propose that MOP be used as an ideal adjuvant therapy to alleviate radiation-induced injuries in cancer patients. (C) 2010 Society of Chemical Industry |
| URI | http://hdl.handle.net/20.500.11897/195744 |
| ISSN | 0022-5142 |
| DOI | 10.1002/jsfa.4077 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
