| Title | Cerebralcare Granule (R), a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion |
| Authors | Sun, Kai Hu, Qin Zhou, Chang-Man Xu, Xiang-Shun Wang, Fang Hu, Bai-He Zhao, Xin-Yong Chang, Xin Chen, Chun-Hua Huang, Ping An, Li-Hua Liu, Yu-Ying Fan, Jing-Yu Wang, Chuan-She Yang, Lei Han, Jing-Yan |
| Affiliation | Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Anat, Beijing 100191, Peoples R China. Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Global ischemia Cerebral microcirculatory disturbance Hippocampal neuron injury Apoptosis Chinese medicine INDUCED MICROVASCULAR DYSFUNCTION INHIBITORY-ACTIVITY DRUG DISCOVERY RAT MESENTERY BRAIN-DAMAGE CASSIA-TORA IN-VITRO STROKE CONSTITUENTS DISTURBANCE |
| Issue Date | 2010 |
| Publisher | journal of ethnopharmacology |
| Citation | JOURNAL OF ETHNOPHARMACOLOGY.2010,130,(2),398-406. |
| Abstract | Aim of the study: Cerebralcare Granule (R) (CG) is a Chinese herb compound preparation that has been used for treatment of cerebrovascular related diseases. However, the effect of post-treatment with CG on ischemia and reperfusion (I/R) induced cerebral injury is so far unclear. Materials and methods: In present study, cerebral global I/R was induced in Mongolian gerbils by clamping bilateral carotid arteries for 30 min followed by reperfusion for 5 days, and CG (0.4 g/kg or 0.8 g/kg) was administrated 3 h after the initiation of reperfusion. Results: Post-treatment with CG for 5 days attenuated the I/R-induced production of hydrogen peroxide in, leukocyte adhesion to, and albumin leakage from cerebral microvessels, and, meanwhile, protected neuron from death, reduced the number of caspase-3- and Bax-positive cells, and increased Bcl-2-positive cells in hippocampal CA1 region. Conclusion: The results suggest that CG given after initiation of reperfusion is able to ameliorate cerebral microvascular dysfunction and hippocampal CA1 neuron damage caused by I/R. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/195239 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2010.05.030 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 |
