| Title | Expression and distribution of immunoglobulin G and its receptors in the human nervous system |
| Authors | Niu, Na Zhang, Jie Guo, Yong Zhao, Yingying Korteweg, Christine Gu, Jiang |
| Affiliation | Shantou Univ Med Coll, Dept Pathol, Shantou 515041, Peoples R China. Weifang Med Univ, Dept Pathol, Weifang 261042, Shandong, Peoples R China. Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100191, Peoples R China. Weifang Med Univ, Dept Human Anat, Weifang 261042, Shandong, Peoples R China. Chinese Acad Med Sci, Dept Pathol & Physiol, Cardiovasc Inst, Beijing 100037, Peoples R China. Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China. Peking Union Med Coll, Beijing 100037, Peoples R China. |
| Keywords | Immunoglobulin G IgG receptor Neuro-immune crosstalk Neuron Nervous system Human NEONATAL FC-RECEPTOR BLOOD-BRAIN-BARRIER LIGHT-CHAIN CELL LINES IGG CNS RECOMBINATION MICROGLIA MOLECULES ANTIBODY |
| Issue Date | 2011 |
| Publisher | international journal of biochemistry cell biology |
| Citation | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY.2011,43,(4),556-563. |
| Abstract | Recently, accumulating evidence has shown that several immunological molecules previously thought to be exclusively expressed by immune cells are also produced by nervous cells. Such molecules are thought to participate in the cross-talk between the immune and the nervous systems. IgG, an important immunological molecule, was traditionally thought to be produced by B lymphocytes only. In this study, extensive expression of neuron-derived IgG was detected throughout the nervous system. Relative quantification indicated that IgG was produced by neural cells at a low constant level. Transcripts of rearranged V-(D)-J segments and recombination activating genes-1 and -2 were also detected. Various IgG receptor types were also detected with distinct distribution patterns at different parts of the central and the peripheral nervous system. Given the widespread expression of IgG and its receptors, IgG most likely has an important biological function in the nervous system and might be classified as an immune mediator involved in neuro-immune crosstalk. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/194760 |
| ISSN | 1357-2725 |
| DOI | 10.1016/j.biocel.2010.12.012 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 |
