Title Anti-fatigue Effect of Renshen Yangrong Decoction ((sic)) in Mice
Authors Chen Yan-zhi
Lin Fei
Li Ping-ping
Affiliation Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Integrat Tradit Chinese & Western Med, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China.
Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China.
Keywords Renshen Yangrong Decoction
loaded swimming time
urea nitrogen
hepatic glycogen
Issue Date 2011
Publisher chinese journal of integrative medicine
Abstract Objective: To explore the anti-fatigue effect of Renshen Yangrong Decoction ((sic), RYD) in mice. Methods: One hundred Kunming mice were randomly divided into 5 groups with 20 mice in each group. The negative control group was treated with distilled water, the positive control group was treated with Shiyiwei Shenqi Tablet ((sic), 1.0 g/kg), the high-, medium- and low-dose RYD groups were treated with 42.0, 21.0 and 10.5 g/kg of RYD daily, respectively, by gastric infusion. At the end of the 7-day treatment, loaded swimming time, organ wet weight and coefficient, serum glucose, urea nitrogen, and hepatic glycogen levels were determined. The outcomes were compared among groups. Results: As compared with the negative control group, the loaded swimming time was significantly increased in the positive control group, specifically the medium- and high-dose RYD groups (P<0.01). In addition, the wet weights and coefficients of the spleen and thymus, and the serum glucose and hepatic glycogen contents were increased, whereas serum urea nitrogen level was significantly decreased in the positive control group and the high dose RYD group (P<0.05 or P<0.01). Conclusion: RYD showed an anti-fatigue effect in mice.
URI http://hdl.handle.net/20.500.11897/193038
ISSN 1672-0415
DOI 10.1007/s11655-011-0879-8
Indexed SCI(E)
Appears in Collections: 北京肿瘤医院

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