| Title | Total Synthesis of (+/-)-Pentalenolactone A Methyl Ester |
| Authors | Liu, Qi Yue, Guozong Wu, Na Lin, Guang Li, Yuanzhen Quan, Junmin Li, Chuang-chuang Wang, Guoxin Yang, Zhen |
| Affiliation | Peking Univ, Shenzhen Grad Sch, Lab Chem Genom, Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China. Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China. Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China. Peking Univ, BNLMS, Beijing 100871, Peoples R China. |
| Keywords | antibiotics Michael olefination Pauson-Khand reaction pentalenolactone A methyl ester total synthesis PAUSON-KHAND REACTION ALKYLIDENE-GAMMA-BUTYROLACTONES FORMAL ASYMMETRIC-SYNTHESIS DL-PENTALENOLACTONE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE CARBONYL-COMPOUNDS ORGANIC-REACTIONS BOND FORMATION STEREOSELECTIVITY CYCLIZATION |
| Issue Date | 2012 |
| Publisher | angewandte chemie international edition |
| Citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.2012,51,(48),12072-12076. |
| Abstract | Ringing it up: The methyl ester of pentalenolactone A has been obtained through the stereoselective synthesis of a cyclopentenone by a combination of the Co-mediated Pauson-Khand reaction (PKR) of enyne 1, and the construction of a quaternary-carbon-based strained ??-methylidene-??-pentyrolactone core through a trimethylsilyl (TMS) mediated, telescoped intramolecular Michael olefination (TIMO) reaction of keto-phosphonate 2. Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| URI | http://hdl.handle.net/20.500.11897/191922 |
| ISSN | 1433-7851 |
| DOI | 10.1002/anie.201206705 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 深圳研究生院待认领 生命科学学院 å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
