| Title | Palladium-catalyzed silyl C(sp(3))-H bond activation |
| Authors | Liang, Yun Geng, Weizhi Wei, Junnian Ouyang, Kunbing Xi, Zhenfeng |
| Affiliation | Peking Univ, Beijing Natl Lab Mol Sci, MOE Key Lab Bioorgan Chem & Mol Engn, Coll Chem, Beijing 100871, Peoples R China. Hunan Normal Univ, Key Lab Resource Fine Proc & Adv Mat Hunan Prov, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China. Hunan Normal Univ, MOE Key Lab Chem Biol & Tradit Chinese Med Res, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China. CAS, SIOC, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China. |
| Keywords | C-H BONDS INTRAMOLECULAR ALKANE ARYLATION SILICON-CARBON HETEROCYCLES CROSS-COUPLING REACTIONS MILD CONDITIONS 6-MEMBERED SILACYCLES METHYL-GROUPS FUNCTIONALIZATION ALPHA SP(2) |
| Issue Date | 2012 |
| Publisher | organic biomolecular chemistry |
| Citation | ORGANIC & BIOMOLECULAR CHEMISTRY.2012,10,(8),1537-1542. |
| Abstract | The first transition-metal-catalyzed activation of silyl C(sp(3))-H bond was realized and synthetically applied. A variety of organic skeletons substituted with SiMe3 groups could undergo the Pd-catalyzed intramolecular coupling reaction, resulting in an unprecedented synthetic method for yielding six-membered silacycles. It was found that the adjacent Si atom played an essential role for the activation of the C(sp(3))-H bond of the SiMe3 group; no activation reaction of the C(sp(3))-H bond of the CMe3 group took place under the same reaction conditions. |
| URI | http://hdl.handle.net/20.500.11897/191912 |
| ISSN | 1477-0520 |
| DOI | 10.1039/c2ob06941e |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
