| Title | Grape-seed proanthocyanidins ameliorate contact hypersensitivity induced by 2,4-dinitrofluorobenzene (DNFB) and inhibit T cell proliferation in vitro |
| Authors | Tang, Qiuqiong Zou, Peng Jin, Haifeng Fu, Jun Yang, Jintao Shang, Lanqin Wei, Xuetao |
| Affiliation | Peking Univ, Hlth Sci Ctr, Dept Toxicol, Sch Publ Hlth, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Toxicol, Sch Publ Hlth, 38 Xue Yuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Contact hypersensitivity MAPK NF-kappa B Proanthocyanidins T cell proliferation EFFECTOR-CELLS DERMATITIS EXTRACT MICE APOPTOSIS ALLERGY ACTIVATION AUTOIMMUNE ARTHRITIS DISEASE |
| Issue Date | 2012 |
| Publisher | 毒理学快报 |
| Citation | TOXICOLOGY LETTERS.2012,210,(1),1-8. |
| Abstract | Contact hypersensitivity (CHS) is a delayed-type hypersensitivity reaction which is mediated by hapten-specific T cells. Strong haptens, such as 2, 4-dinitrofluorobenzene (DNFB) can induce it. Grape seed proanthocyanidins extract (GSPs), which is an antioxidant derived from grape seeds, has been reported to possess a variety of potent properties. However, few reports demonstrated the effects of GSPs on contact hypersensitivity. Therefore, the present study was devised to describe the role of GSPs on a mouse model of experimental CHS induced by DNFB and try to explore the possible underlying mechanisms. We observed that, GSPs when orally administrated into the CHS mice, inhibited the aggravation of inflammation. After administration of GSPs, there was obvious fewer inflammatory cell infiltration in the inflamed ears. Ear swelling after challenge was significantly reduced. In addition, we investigated the effects of GSPs on T cells in vitro, which play critical role during the progress of CHS. It was found that GSPs inhibited proliferative activity of T cells by blocking the activation of mitogen-activated protein kinases (MAPK) and NF-kappa B signaling pathways. Collectively, these results showed that GSPs has protective effect on CHS induced by DNFB and it also could inhibit the proliferation ability of T cells in vitro, suggesting the potential of GSPs as new and effective compound for the treatment of T-cell mediated inflammatory diseases. (C) 2012 Published by Elsevier Ireland Ltd. |
| URI | http://hdl.handle.net/20.500.11897/191720 |
| ISSN | 0378-4274 |
| DOI | 10.1016/j.toxlet.2012.01.009 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 医学部待认领 |
