| Title | microRNAs and ceRNAs: RNA networks in pathogenesis of cancer |
| Authors | Su, Xiangqian Xing, Jiadi Wang, Zaozao Chen, Lei Cui, Ming Jiang, Beihai |
| Affiliation | Peking Univ Canc Hosp & Inst, Dept Minimally Invas Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China. |
| Keywords | miRNA ceRNA cancer MAMMALIAN MESSENGER-RNAS LONG NONCODING RNA MOUSE MODEL IN-VIVO EXPRESSION TARGETS DIFFERENTIATION MELANOMA REVEALS REGION |
| Issue Date | 2013 |
| Publisher | 中国癌症研究英文版 |
| Citation | CHINESE JOURNAL OF CANCER RESEARCH.2013,25,(2),235-239. |
| Abstract | microRNAs (iniRNAs) are a class of endogenous, single-stranded non-coding RNAs of 20-23 nucleotides in length, functioning as negative regulators of gene expression at the post-transcriptional level. The dysregulation of miRNAs has been demonstrated to play critical roles in tumorigenesis, either through inhibiting tumor suppressor genes or activating oncogenes inappropriately. Besides their promising clinical applications in cancer diagnosis and treatment, recent studies have uncovered that miRNAs could act as a regulatory language, through which messenger RNAs, transcribed pseudogenes, and long noncoding RNAs crosstalk with each other and form a novel regulatory network. RNA transcripts involved in this network have been termed as competing endogenous RNAs (ceRNAs), since they influence each other's level by competing for the same pool of miRNAs through miRNA response elements (MREs) on their target transcripts. The discovery of miRNA-ceRNA network not only provides the possibility of an additional level of post-transcriptional regulation, but also dictates a reassessment of the existing regulatory pathways involved in cancer initiation and progression. |
| URI | http://hdl.handle.net/20.500.11897/190546 |
| ISSN | 1000-9604 |
| DOI | 10.3978/j.issn.1000-9604.2013.03.08 |
| Indexed | SCI(E) PubMed 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 北京肿瘤医院 |
