| Title | Elevated level of peripheral CD8(+)CD28(-) T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy |
| Authors | Song, Guohong Wang, Xiaoli Jia, Jun Yuan, Yanhua Wan, Fengling Zhou, Xinna Yang, Huabing Ren, Jun Gu, Jiezhun Lyerly, Herbert Kim |
| Affiliation | Peking Univ, Canc Hosp & Inst, Minist Educ, Dept Med Oncol,Key Lab Carcinogenesis & Translat, Beijing 100142, Peoples R China. Capital Med Univ, Ctr Canc, Beijing Shijitan Hosp, Beijing 100038, Peoples R China. Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA. Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. Capital Med Univ, Ctr Canc, Beijing Shijitan Hosp, 10 TieyiRd, Beijing 100038, Peoples R China. |
| Keywords | Regulatory T lymphocyte Peripheral blood Metastatic breast cancer Progression-free survival Cytokine SYSTEMIC IMMUNE ACTIVATION CELL LUNG-CANCER COLORECTAL-CANCER IMMUNOSUPPRESSIVE NETWORKS DENDRITIC CELLS TUMOR-IMMUNITY BLOOD PHENOTYPE CARCINOMA DISEASE |
| Issue Date | 2013 |
| Publisher | cancer immunology immunotherapy |
| Citation | CANCER IMMUNOLOGY IMMUNOTHERAPY.2013,62,(6),1123-1130. |
| Abstract | Suppression of cellular immunity resulting from tumorigenesis and/or therapy might promote cancer cells' growth, progression and invasion. Here, we explored whether T lymphocyte subtypes from peripheral blood of metastatic breast cancer (MBC) female patients could be used as alternative surrogate markers for cancer progress. Additionally, plasma levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IFN-gamma, and transforming growth factor-beta 1 were quantitated from MBC and healthy volunteers. This study included 89 female MBC patients during the post-salvage chemotherapy follow-up and 50 age- and sex-matched healthy volunteers as control. The percentages of T lymphocyte subpopulations from peripheral blood and plasma levels of cytokines were measured. Both CD8(+)CD28(-) and CD4(+)CD25(+) were elevated in MBC patients compared to the control cohort (P < 0.05). In contrast, CD3(+) and CD8(+)CD28(+)cells were significantly lower in MBC patients (P < 0.0001, P = 0.045, respectively). MBC patients had elevated levels of immunosuppressive cytokines IL-6 and IL-10. Patients with elevated CD8(+)CD28(-) and CD4(+)CD25(+) cells showed increased levels of IL-6, and only patients with elevated CD8(+)CD28(-) had decreased interferon-gamma. Univariate analysis indicated increased CD3(+)CD4(+) or CD8(+)CD28(+)correlated with prolonged progression-free survival (PFS), while elevated CD8(+)CD28(-)associated with shorten PFS. The percent of CD8(+)CD28(-) T lymphocytes is an independent predictor for PFS through multivariate analysis. This study suggests that progressive elevated levels of CD8(+)CD28(-) suppressor T lymphocytes represent a novel independent predictor of PFS during post-chemotherapy follow-up. |
| URI | http://hdl.handle.net/20.500.11897/190538 |
| ISSN | 0340-7004 |
| DOI | 10.1007/s00262-013-1424-8 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
