| Title | The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
| Authors | Zhang, Yao Bao, Li Lu, Jin Liu, Kai-Yan Li, Jin-Lan Qin, Ya-Zhen Chen, Huan Li, Ling-Di Kong, Yuan Shi, Hong-Xia Lai, Yue-Yun Liu, Yan-Rong Jiang, Bin Chen, Shan-Shan Huang, Xiao-Jun Ruan, Guo-Rui |
| Affiliation | Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China. Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Beijing 100044, Peoples R China. Peking Univ, Peoples Hosp, 11 Xi Zhi Men South St, Beijing 100044, Peoples R China. |
| Keywords | Cancer-testis antigen gene Multiple myeloma Real-time quantitative polymerase chain reaction RESIDUAL DISEASE EXPRESSION CT7 MALIGNANCIES MAGE-C1/CT7 PROGNOSIS MARKERS PCR |
| Issue Date | 2014 |
| Publisher | molecular cancer |
| Citation | MOLECULAR CANCER.2014,13. |
| Abstract | Background: Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications. Methods: Real-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients. Results: In the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course. Conclusion: MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM. |
| URI | http://hdl.handle.net/20.500.11897/190254 |
| ISSN | 1476-4598 |
| DOI | 10.1186/1476-4598-13-25 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 |
